Adenosine A agonists as therapy for glomerulonephritis

Garcia et al. report the utility of pharmacological activation of the adenosine A(2A) receptor (A(2A)R) in preserving renal function, reversing fibrosis, and reducing macrophage infiltration and inflammatory activation in rat nephrotoxic nephritis. The role of A(2A)R activation in determining outcom...

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Veröffentlicht in:	Kidney international 2011-08, Vol.80 (4), p.329-331
Hauptverfasser:	Ferenbach, David A, Hughes, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine A2 Receptor Agonists - pharmacology Animals Anti-Inflammatory Agents - pharmacology Glomerulonephritis - prevention & control Kidney - drug effects Male Phenethylamines - pharmacology Receptor, Adenosine A2A - drug effects
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Zusammenfassung:	Garcia et al. report the utility of pharmacological activation of the adenosine A(2A) receptor (A(2A)R) in preserving renal function, reversing fibrosis, and reducing macrophage infiltration and inflammatory activation in rat nephrotoxic nephritis. The role of A(2A)R activation in determining outcome in renal inflammation is discussed.
ISSN:	0085-2538 1523-1755
DOI:	10.1038/ki.2011.167