Stimulation of ALK by the growth factor midkine renders glioma cells resistant to autophagy-mediated cell death

Δ 9 -tetrahydrocannabinol (THC), the main active component of marijuana, promotes cancer cell death via autophagy stimulation. We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cel...

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Veröffentlicht in:	Autophagy 2011-09, Vol.7 (9), p.1071-1073
Hauptverfasser:	Lorente, Mar, Torres, Sofia, Salazar, María, Carracedo, Arkaitz, Hernández-Tiedra, Sonia, Rodríguez-Fornés, Fátima, García-Taboada, Elena, Meléndez, Bárbara, Mollejo, Manuela, Campos-Martín, Yolanda, Barcia, Juan A., Guzmán, Manuel, Velasco, Guillermo
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplastic Lymphoma Kinase Autophagy - drug effects Binding Biology Bioscience Calcium Cancer Cell Cycle Cytokines - pharmacology Dronabinol - pharmacology Glioma - enzymology Glioma - pathology Humans Intercellular Signaling Peptides and Proteins - pharmacology Landes Midkine Models, Biological Organogenesis Proteins Receptor Protein-Tyrosine Kinases - metabolism
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Zusammenfassung:	Δ 9 -tetrahydrocannabinol (THC), the main active component of marijuana, promotes cancer cell death via autophagy stimulation. We find that activation of the tyrosine kinase receptor ALK by its ligand midkine interferes with the signaling mechanism by which THC promotes autophagy-mediated glioma cell death.
ISSN:	1554-8627 1554-8635
DOI:	10.4161/auto.7.9.15866