ROLE OF TESTOSTERONE IN THE DEVELOPMENT OF RADIATION-INDUCED PROSTATE CARCINOMA IN RATS

An attempt was made to study the effect of testosterone on the development of X-ray-induced prostate cancer in rats. Five-week-old male Sprague-Dawley rats were castrated and replaced with 2.5 or 5.0mg of testosterone thereafter once a month for the life span. At 6 weeks of age, they were locally (p...

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Veröffentlicht in:	GANN Japanese Journal of Cancer Research 1978/10/31, Vol.69(5), pp.723-726
Hauptverfasser:	TAKIZAWA, Shoichi, HIROSE, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - etiology Adenocarcinoma, Mucinous - etiology Animals Castration Male Neoplasms, Experimental - etiology Neoplasms, Radiation-Induced - etiology Prostate cancer Prostatic Neoplasms - etiology Radiation carcinogenesis Rats Sprague-Dawley rat Testosterone Testosterone - pharmacology
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Zusammenfassung:	An attempt was made to study the effect of testosterone on the development of X-ray-induced prostate cancer in rats. Five-week-old male Sprague-Dawley rats were castrated and replaced with 2.5 or 5.0mg of testosterone thereafter once a month for the life span. At 6 weeks of age, they were locally (pelvic region) irradiated with a total of 5, 000 rad (5×1, 000 rad) of X-ray at an interval of 2 or 3 days. Prostate cancer developed only in the castrated and testosteronetreated rats with an incidence of 4/12 (33.3%) during the period of 7 to 11 months after irradiation, none in the castrated (0/13) and non-castrated rats (0/11). This indicated a promoting role of testosterone in the genesis of prostate cancer.
ISSN:	0016-450X
DOI:	10.20772/cancersci1959.69.5_723