A phase I study of toremifene
A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.
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| Veröffentlicht in: | Breast cancer research and treatment 1990-08, Vol.16, p.S27-S29 |
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| container_title | Breast cancer research and treatment |
| container_volume | 16 |
| creator | TOMINAGA, T ABE, O IZUO, M NOMURA, Y |
| description | A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild. |
| format | Article |
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Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.</description><identifier>ISSN: 0167-6806</identifier><identifier>EISSN: 1573-7217</identifier><identifier>PMID: 2149281</identifier><identifier>CODEN: BCTRD6</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Administration, Oral ; Adult ; Aged ; Anorexia - chemically induced ; Antineoplastic agents ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - pharmacokinetics ; Biological and medical sciences ; Chemotherapy ; Drug Evaluation ; Estrogen Antagonists - administration & dosage ; Estrogen Antagonists - adverse effects ; Estrogen Antagonists - pharmacokinetics ; Female ; Humans ; Japan ; Medical sciences ; Middle Aged ; Nausea - chemically induced ; Neoplasms - metabolism ; Pharmacology. Drug treatments ; Tamoxifen - administration & dosage ; Tamoxifen - adverse effects ; Tamoxifen - analogs & derivatives ; Tamoxifen - pharmacokinetics ; Toremifene</subject><ispartof>Breast cancer research and treatment, 1990-08, Vol.16, p.S27-S29</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23910,23911,25119</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19506165$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2149281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOMINAGA, T</creatorcontrib><creatorcontrib>ABE, O</creatorcontrib><creatorcontrib>IZUO, M</creatorcontrib><creatorcontrib>NOMURA, Y</creatorcontrib><title>A phase I study of toremifene</title><title>Breast cancer research and treatment</title><addtitle>Breast Cancer Res Treat</addtitle><description>A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Anorexia - chemically induced</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Drug Evaluation</subject><subject>Estrogen Antagonists - administration & dosage</subject><subject>Estrogen Antagonists - adverse effects</subject><subject>Estrogen Antagonists - pharmacokinetics</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nausea - chemically induced</subject><subject>Neoplasms - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Tamoxifen - administration & dosage</subject><subject>Tamoxifen - adverse effects</subject><subject>Tamoxifen - analogs & derivatives</subject><subject>Tamoxifen - pharmacokinetics</subject><subject>Toremifene</subject><issn>0167-6806</issn><issn>1573-7217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9jr1qwzAURkVpSd20jxDQ0tFwr2RdSWMI_QkEsrRzuJIl6hInxnKGvH0LNZ3OcA4f342o0FhdW4X2VlSAZGtyQPfioZRvAPAW_EIsFDZeOazEai2HLy5JbmWZLu1VnrOczmPqu5xO6VHcZT6W9DRzKT5fXz427_Vu_7bdrHf1gOSm2jM7G5Iik6wKseWUuQmkOQGxBsRGxZxJg1NBKYSYQ2ysZxPb6EJ0eilWf7vDJfSpPQxj1_N4Pcw3f_3z7LlEPuaRT7Er_xl6A4Rk9A8EEEWu</recordid><startdate>19900801</startdate><enddate>19900801</enddate><creator>TOMINAGA, T</creator><creator>ABE, O</creator><creator>IZUO, M</creator><creator>NOMURA, Y</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19900801</creationdate><title>A phase I study of toremifene</title><author>TOMINAGA, T ; ABE, O ; IZUO, M ; NOMURA, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p168t-9aa87be265e72bcdaefa4b63ae06a301142cff63082b2210cfbc479a5cdc8bc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Aged</topic><topic>Anorexia - chemically induced</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Drug Evaluation</topic><topic>Estrogen Antagonists - administration & dosage</topic><topic>Estrogen Antagonists - adverse effects</topic><topic>Estrogen Antagonists - pharmacokinetics</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nausea - chemically induced</topic><topic>Neoplasms - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Tamoxifen - administration & dosage</topic><topic>Tamoxifen - adverse effects</topic><topic>Tamoxifen - analogs & derivatives</topic><topic>Tamoxifen - pharmacokinetics</topic><topic>Toremifene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOMINAGA, T</creatorcontrib><creatorcontrib>ABE, O</creatorcontrib><creatorcontrib>IZUO, M</creatorcontrib><creatorcontrib>NOMURA, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Breast cancer research and treatment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOMINAGA, T</au><au>ABE, O</au><au>IZUO, M</au><au>NOMURA, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A phase I study of toremifene</atitle><jtitle>Breast cancer research and treatment</jtitle><addtitle>Breast Cancer Res Treat</addtitle><date>1990-08-01</date><risdate>1990</risdate><volume>16</volume><spage>S27</spage><epage>S29</epage><pages>S27-S29</pages><issn>0167-6806</issn><eissn>1573-7217</eissn><coden>BCTRD6</coden><abstract>A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>2149281</pmid></addata></record> |
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| identifier | ISSN: 0167-6806 |
| ispartof | Breast cancer research and treatment, 1990-08, Vol.16, p.S27-S29 |
| issn | 0167-6806 1573-7217 |
| language | eng |
| recordid | cdi_pubmed_primary_2149281 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Administration, Oral Adult Aged Anorexia - chemically induced Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Biological and medical sciences Chemotherapy Drug Evaluation Estrogen Antagonists - administration & dosage Estrogen Antagonists - adverse effects Estrogen Antagonists - pharmacokinetics Female Humans Japan Medical sciences Middle Aged Nausea - chemically induced Neoplasms - metabolism Pharmacology. Drug treatments Tamoxifen - administration & dosage Tamoxifen - adverse effects Tamoxifen - analogs & derivatives Tamoxifen - pharmacokinetics Toremifene |
| title | A phase I study of toremifene |
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