A phase I study of toremifene

A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.

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Bibliographische Detailangaben
Veröffentlicht in:	Breast cancer research and treatment 1990-08, Vol.16, p.S27-S29
Hauptverfasser:	TOMINAGA, T, ABE, O, IZUO, M, NOMURA, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Anorexia - chemically induced Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Biological and medical sciences Chemotherapy Drug Evaluation Estrogen Antagonists - administration & dosage Estrogen Antagonists - adverse effects Estrogen Antagonists - pharmacokinetics Female Humans Japan Medical sciences Middle Aged Nausea - chemically induced Neoplasms - metabolism Pharmacology. Drug treatments Tamoxifen - administration & dosage Tamoxifen - adverse effects Tamoxifen - analogs & derivatives Tamoxifen - pharmacokinetics Toremifene
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Beschreibung
Zusammenfassung:	A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10-480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2-6 hours after each oral administration. Side effects were generally mild.
ISSN:	0167-6806 1573-7217