A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamics

A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamics

Histone acetylation modulates histone occupancy both at promoters and in coding sequences. Based on our recent observation that HDACs in the budding yeast, Saccharomyces cerevisiae, are co-transcriptionally recruited to coding regions by elongating polymerases, we propose a model in which Pol II fac...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Transcription 2011-03, Vol.2 (2), p.78-81
Hauptverfasser: Spain, Marla M., Govind, Chhabi K.
Format: Artikel
Sprache:eng
Schlagworte:
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Point-of-View
Proteins
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Histone acetylation modulates histone occupancy both at promoters and in coding sequences. Based on our recent observation that HDACs in the budding yeast, Saccharomyces cerevisiae, are co-transcriptionally recruited to coding regions by elongating polymerases, we propose a model in which Pol II facilitates recruitment of chromatin remodeling complexes as well as other factors required for productive elongation.
ISSN:2154-1264
2154-1272
DOI:10.4161/trns.2.2.14638