P2X1 Receptor-Mediated Vasoconstriction of Afferent Arterioles in Angiotensin II–Infused Hypertensive Rats Fed a High-Salt Diet

Experiments tested the hypothesis that P2 receptor reactivity is impaired in angiotensin (Ang) II hypertensive rats fed an 8%NaCl diet (Ang II+HS). Juxtamedullary afferent arteriolar autoregulatory behavior was determined over a pressure range of 65 to 200 mm Hg. Arteriolar responsiveness to P2X1 (β...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2011-04, Vol.57 (4), p.780-787
Hauptverfasser:	Inscho, Edward W, Cook, Anthony K, Clarke, Andrea, Zhang, Shali, Guan, Zhengrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Arterial hypertension. Arterial hypotension Arterioles - drug effects Arterioles - metabolism Arterioles - physiopathology Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Blotting, Western Cardiology. Vascular system Experimental diseases Homeostasis - drug effects Homeostasis - physiology Hypertension - chemically induced Hypertension - metabolism Hypertension - physiopathology Kidney - drug effects Kidney - metabolism Kidney - physiopathology Male Medical sciences Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Rats Rats, Sprague-Dawley Receptors, Purinergic P2X1 - metabolism Renal Circulation - drug effects Renal Circulation - physiology Sodium, Dietary Vasoconstriction - drug effects Vasoconstriction - physiology
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Zusammenfassung:	Experiments tested the hypothesis that P2 receptor reactivity is impaired in angiotensin (Ang) II hypertensive rats fed an 8%NaCl diet (Ang II+HS). Juxtamedullary afferent arteriolar autoregulatory behavior was determined over a pressure range of 65 to 200 mm Hg. Arteriolar responsiveness to P2X1 (β,γ-methylene ATP) or P2Y2 receptor (uridine triphosphate) activation was determined in vitro. Systolic blood pressure averaged 126±3 and 225±4 mm Hg in control and Ang II+HS rats, respectively (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.110.168955