Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2011-03, Vol.55 (3), p.1088-1096
Hauptverfasser:	MILLS, Scott D, EAKIN, Ann E, WEI YANG, STOKES, Suzanne S, BUURMAN, Ed T, NEWMAN, Joseph V, NING GAO, HUYNH, Hoan, JOHNSON, Kenneth D, LAHIRI, Sushmita, SHAPIRO, Adam B, WALKUP, Grant K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenylation Animal models Animals Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibacterial activity Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Colony-forming cells DNA biosynthesis DNA Ligases DNA Ligases - antagonists & inhibitors Enzyme Inhibitors Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Enzymes Escherichia coli Female Haemophilus influenzae high-throughput screening Humans Infection Kinetics Lung Mechanisms of Action: Physiological Effects Medical sciences Mice Microbial Sensitivity Tests Moraxella catarrhalis Mutation Mycoplasma pneumoniae Okazaki fragments Pathogens Phages Pharmacology. Drug treatments Recombination Replication Staphylococcal Infections - drug therapy Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - pathogenicity Streptococcus pneumoniae Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - pathogenicity Streptococcus pyogenes X-ray crystallography
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Zusammenfassung:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.01181-10