The importance of depressive syndromes for incipient Alzheimer-type dementia in advanced age

Based on epidemiological data on the risk for dementia conveyed by depression, we report recent findings on the effects of depressive disorders on cognition in later life and its relationship to incipient Alzheimer's disease. We review the current literature on possible mechanisms underlying th...

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Veröffentlicht in:	Nervenarzt 2011-09, Vol.82 (9), p.1140
Hauptverfasser:	Rapp, M A, Hellweg, R, Heinz, A
Format:	Artikel
Sprache:	ger
Schlagworte:	Age Factors Aged Alzheimer Disease - diagnosis Alzheimer Disease - epidemiology Alzheimer Disease - pathology Alzheimer Disease - physiopathology Animals Brain - pathology Brain - physiopathology Comorbidity Depressive Disorder, Major - diagnosis Depressive Disorder, Major - epidemiology Depressive Disorder, Major - pathology Depressive Disorder, Major - physiopathology Disease Models, Animal Disease Progression Humans Longitudinal Studies Neurofibrillary Tangles - pathology Neuropsychological Tests Plaque, Amyloid - pathology Plaque, Amyloid - physiopathology Risk Factors
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Beschreibung
Zusammenfassung:	Based on epidemiological data on the risk for dementia conveyed by depression, we report recent findings on the effects of depressive disorders on cognition in later life and its relationship to incipient Alzheimer's disease. We review the current literature on possible mechanisms underlying the depression-dementia association. The findings summarized in this review underline the central importance of depressive disorders for the diagnosis and treatment of psychiatric disorders in later life.
ISSN:	1433-0407
DOI:	10.1007/s00115-010-3129-y