Chitosan hydrogel with terbinafine - an evaluation of drug release

The aim of this study was to evaluate rheological properties and release of terbinafine (an antifungal drug) from chitosan hydrogels, and test some additives as possible solvents, preservatives and potential chemical penetration enhancers. The release of terbinafine was better from hydrogel with gly...

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Veröffentlicht in:	Pharmazie 2010-07, Vol.65 (7), p.523-524
Hauptverfasser:	Matušová, D., Vitková, Z., Truplová, E., Herdová, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - administration & dosage Antifungal Agents - chemistry Chitosan - chemistry Excipients Hydrogels Kinetics Naphthalenes - administration & dosage Naphthalenes - chemistry Polysorbates Rheology Solubility Surface-Active Agents Viscosity
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Beschreibung
Zusammenfassung:	The aim of this study was to evaluate rheological properties and release of terbinafine (an antifungal drug) from chitosan hydrogels, and test some additives as possible solvents, preservatives and potential chemical penetration enhancers. The release of terbinafine was better from hydrogel with glycerol (plastic flow), than that from hydrogel with propylene glycol (thixotropic flow), the presence of Tween 80 showed a negative influence on drug release from both types.
ISSN:	0031-7144
DOI:	10.1691/ph.2010.9404