Directed Stem Cell Differentiation: The Role of Physical Forces

Directed Stem Cell Differentiation: The Role of Physical Forces

Abstract A number of factors contribute to the control of stem cell fate. In particular, the evidence for how physical forces control the stem cell differentiation program is now accruing. In this review, the authors discuss the types of physical forces: mechanical forces, cell shape, extracellular...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell communication & adhesion 2010-04, Vol.17 (2), p.48-54
Hauptverfasser: Clause, Kelly C., Liu, Li J., Tobita, Kimimasa
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Differentiation
Cell Shape
cell-cell contacts
differentiation
ECM properties
Extracellular Matrix - metabolism
geometric controls
Humans
mechanical force
Mice
morphogenic factors
Stem Cells - cytology
Stress, Mechanical
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract A number of factors contribute to the control of stem cell fate. In particular, the evidence for how physical forces control the stem cell differentiation program is now accruing. In this review, the authors discuss the types of physical forces: mechanical forces, cell shape, extracellular matrix geometry/properties, and cell-cell contacts and morphogenic factors, which evidence suggests play a role in influencing stem cell fate.
ISSN:1541-9061
1543-5180
DOI:10.3109/15419061.2010.492535