Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function

N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2010-05, Vol.107 (19), p.8575-8580
Hauptverfasser: Stanczyk, Nina M, Brookfield, John F.Y, Ignell, Rickard, Logan, James G, Field, Linda M
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container_issue 19
container_start_page 8575
container_title Proceedings of the National Academy of Sciences - PNAS
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creator Stanczyk, Nina M
Brookfield, John F.Y
Ignell, Rickard
Logan, James G
Field, Linda M
description N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that were insensitive to DEET, and the selection of either sensitive or insensitive groups of females with males of unknown sensitivity over several generations resulted in two populations with different proportions of insensitive females. Crossing experiments showed the "insensitivity" trait to be dominant. Electroantennography showed a reduced response to DEET in the selected insensitive line compared with the selected sensitive line, and single sensillum recordings identified DEET-sensitive sensilla that were nonresponders in the insensitive line. This study suggests that behavioral insensitivity to DEET in A. aegypti is a genetically determined dominant trait and resides in changes in sensillum function.
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subjects Aedes - drug effects
Aedes - genetics
Aedes - ultrastructure
Aedes aegypti
Animal behavior
Animal populations
Animal Structures - drug effects
Animal Structures - physiology
Animal Structures - ultrastructure
Animals
Behavior, Animal - drug effects
behavioral repellency
Behavioral Sciences Biology
Biological Sciences
Crosses, Genetic
deet
DEET - pharmacology
electroantennography
electrophysiology
Etologi
Female
Female animals
females
Genetics
heritability
Indoles
inheritance (genetics)
insect behavior
Insect pests
Insecticide Resistance - drug effects
Insecticides
line differences
Male
Mosquitoes
Mosquitos
Neurons
neurophysiology
Odors
olfactory receptor neurons
Olfactory Receptor Neurons - drug effects
Olfactory Receptor Neurons - metabolism
olfactory receptors
Personality traits
Phenotypic traits
Quantitative Trait, Heritable
Receptors
Resistance to control
Selection, Genetic
Sensilla
Studies
title Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function
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