Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function
N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that...
Gespeichert in:
Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2010-05, Vol.107 (19), p.8575-8580 |
---|---|
Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 8580 |
---|---|
container_issue | 19 |
container_start_page | 8575 |
container_title | Proceedings of the National Academy of Sciences - PNAS |
container_volume | 107 |
creator | Stanczyk, Nina M Brookfield, John F.Y Ignell, Rickard Logan, James G Field, Linda M |
description | N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that were insensitive to DEET, and the selection of either sensitive or insensitive groups of females with males of unknown sensitivity over several generations resulted in two populations with different proportions of insensitive females. Crossing experiments showed the "insensitivity" trait to be dominant. Electroantennography showed a reduced response to DEET in the selected insensitive line compared with the selected sensitive line, and single sensillum recordings identified DEET-sensitive sensilla that were nonresponders in the insensitive line. This study suggests that behavioral insensitivity to DEET in A. aegypti is a genetically determined dominant trait and resides in changes in sensillum function. |
doi_str_mv | 10.1073/pnas.1001313107 |
format | Article |
fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmed_primary_20439757</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>25681458</jstor_id><sourcerecordid>25681458</sourcerecordid><originalsourceid>FETCH-LOGICAL-c559t-1b645677335c3cbe108d15a122c16f1b576da1fac65248d24e7e9c5046c38c5d3</originalsourceid><addsrcrecordid>eNqFkkuP0zAUhSMEYsrAmhVgsWEVxs_Y2SANQ3lII7FgZm05zk3qKnWK7RR1wX_HoWXKsEFe-Mr-zvG91imK5wS_JViyi603MVeYsLywfFAsCK5JWfEaPywWGFNZKk75WfEkxjXGuBYKPy7OKOaslkIuip_vYWV2bgxmQM5H8NElt3Npj9KIPiyXN_kUXUILERno99vkkMsl6sFDctYMwx61kCBsnIcWpWBcQgGia53vZ61dGd9ndS5_uw_DtEHd5G1yo39aPOrMEOHZcT8vbj8ub64-l9dfP325urwurRB1KklTcVFJyZiwzDZAsGqJMIRSS6qONEJWrSGdsZWgXLWUg4TaCswry5QVLTsvyoNv_AHbqdHb4DYm7PVonI7D1JgwbzqCFpgKnvl3Bz7DG2gt-DzYcE92_8a7le7HnaZK1YxW2eDN0SCM3yeISW9ctDAMxsM4RS3zPHVdK_F_kjFCOWM0k6__IdfjFHz-N03nAFScznYXB8iGMcYA3V3TBOs5MnqOjD5FJite_j3rHf8nIxl4dQRm5clOalJrJeT86IsDsY5pDCcHUSnChTo5dGbUpg8u6ttvc8-YKE4oY-wX_V7cLw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201316425</pqid></control><display><type>article</type><title>Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function</title><source>Jstor Complete Legacy</source><source>MEDLINE</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Stanczyk, Nina M ; Brookfield, John F.Y ; Ignell, Rickard ; Logan, James G ; Field, Linda M</creator><creatorcontrib>Stanczyk, Nina M ; Brookfield, John F.Y ; Ignell, Rickard ; Logan, James G ; Field, Linda M ; Sveriges lantbruksuniversitet</creatorcontrib><description>N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that were insensitive to DEET, and the selection of either sensitive or insensitive groups of females with males of unknown sensitivity over several generations resulted in two populations with different proportions of insensitive females. Crossing experiments showed the "insensitivity" trait to be dominant. Electroantennography showed a reduced response to DEET in the selected insensitive line compared with the selected sensitive line, and single sensillum recordings identified DEET-sensitive sensilla that were nonresponders in the insensitive line. This study suggests that behavioral insensitivity to DEET in A. aegypti is a genetically determined dominant trait and resides in changes in sensillum function.</description><identifier>ISSN: 0027-8424</identifier><identifier>ISSN: 1091-6490</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1001313107</identifier><identifier>PMID: 20439757</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Aedes - drug effects ; Aedes - genetics ; Aedes - ultrastructure ; Aedes aegypti ; Animal behavior ; Animal populations ; Animal Structures - drug effects ; Animal Structures - physiology ; Animal Structures - ultrastructure ; Animals ; Behavior, Animal - drug effects ; behavioral repellency ; Behavioral Sciences Biology ; Biological Sciences ; Crosses, Genetic ; deet ; DEET - pharmacology ; electroantennography ; electrophysiology ; Etologi ; Female ; Female animals ; females ; Genetics ; heritability ; Indoles ; inheritance (genetics) ; insect behavior ; Insect pests ; Insecticide Resistance - drug effects ; Insecticides ; line differences ; Male ; Mosquitoes ; Mosquitos ; Neurons ; neurophysiology ; Odors ; olfactory receptor neurons ; Olfactory Receptor Neurons - drug effects ; Olfactory Receptor Neurons - metabolism ; olfactory receptors ; Personality traits ; Phenotypic traits ; Quantitative Trait, Heritable ; Receptors ; Resistance to control ; Selection, Genetic ; Sensilla ; Studies</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (19), p.8575-8580</ispartof><rights>Copyright National Academy of Sciences May 11, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-1b645677335c3cbe108d15a122c16f1b576da1fac65248d24e7e9c5046c38c5d3</citedby><cites>FETCH-LOGICAL-c559t-1b645677335c3cbe108d15a122c16f1b576da1fac65248d24e7e9c5046c38c5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/107/19.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25681458$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25681458$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20439757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://res.slu.se/id/publ/50254$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Stanczyk, Nina M</creatorcontrib><creatorcontrib>Brookfield, John F.Y</creatorcontrib><creatorcontrib>Ignell, Rickard</creatorcontrib><creatorcontrib>Logan, James G</creatorcontrib><creatorcontrib>Field, Linda M</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><title>Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that were insensitive to DEET, and the selection of either sensitive or insensitive groups of females with males of unknown sensitivity over several generations resulted in two populations with different proportions of insensitive females. Crossing experiments showed the "insensitivity" trait to be dominant. Electroantennography showed a reduced response to DEET in the selected insensitive line compared with the selected sensitive line, and single sensillum recordings identified DEET-sensitive sensilla that were nonresponders in the insensitive line. This study suggests that behavioral insensitivity to DEET in A. aegypti is a genetically determined dominant trait and resides in changes in sensillum function.</description><subject>Aedes - drug effects</subject><subject>Aedes - genetics</subject><subject>Aedes - ultrastructure</subject><subject>Aedes aegypti</subject><subject>Animal behavior</subject><subject>Animal populations</subject><subject>Animal Structures - drug effects</subject><subject>Animal Structures - physiology</subject><subject>Animal Structures - ultrastructure</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>behavioral repellency</subject><subject>Behavioral Sciences Biology</subject><subject>Biological Sciences</subject><subject>Crosses, Genetic</subject><subject>deet</subject><subject>DEET - pharmacology</subject><subject>electroantennography</subject><subject>electrophysiology</subject><subject>Etologi</subject><subject>Female</subject><subject>Female animals</subject><subject>females</subject><subject>Genetics</subject><subject>heritability</subject><subject>Indoles</subject><subject>inheritance (genetics)</subject><subject>insect behavior</subject><subject>Insect pests</subject><subject>Insecticide Resistance - drug effects</subject><subject>Insecticides</subject><subject>line differences</subject><subject>Male</subject><subject>Mosquitoes</subject><subject>Mosquitos</subject><subject>Neurons</subject><subject>neurophysiology</subject><subject>Odors</subject><subject>olfactory receptor neurons</subject><subject>Olfactory Receptor Neurons - drug effects</subject><subject>Olfactory Receptor Neurons - metabolism</subject><subject>olfactory receptors</subject><subject>Personality traits</subject><subject>Phenotypic traits</subject><subject>Quantitative Trait, Heritable</subject><subject>Receptors</subject><subject>Resistance to control</subject><subject>Selection, Genetic</subject><subject>Sensilla</subject><subject>Studies</subject><issn>0027-8424</issn><issn>1091-6490</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuP0zAUhSMEYsrAmhVgsWEVxs_Y2SANQ3lII7FgZm05zk3qKnWK7RR1wX_HoWXKsEFe-Mr-zvG91imK5wS_JViyi603MVeYsLywfFAsCK5JWfEaPywWGFNZKk75WfEkxjXGuBYKPy7OKOaslkIuip_vYWV2bgxmQM5H8NElt3Npj9KIPiyXN_kUXUILERno99vkkMsl6sFDctYMwx61kCBsnIcWpWBcQgGia53vZ61dGd9ndS5_uw_DtEHd5G1yo39aPOrMEOHZcT8vbj8ub64-l9dfP325urwurRB1KklTcVFJyZiwzDZAsGqJMIRSS6qONEJWrSGdsZWgXLWUg4TaCswry5QVLTsvyoNv_AHbqdHb4DYm7PVonI7D1JgwbzqCFpgKnvl3Bz7DG2gt-DzYcE92_8a7le7HnaZK1YxW2eDN0SCM3yeISW9ctDAMxsM4RS3zPHVdK_F_kjFCOWM0k6__IdfjFHz-N03nAFScznYXB8iGMcYA3V3TBOs5MnqOjD5FJite_j3rHf8nIxl4dQRm5clOalJrJeT86IsDsY5pDCcHUSnChTo5dGbUpg8u6ttvc8-YKE4oY-wX_V7cLw</recordid><startdate>20100511</startdate><enddate>20100511</enddate><creator>Stanczyk, Nina M</creator><creator>Brookfield, John F.Y</creator><creator>Ignell, Rickard</creator><creator>Logan, James G</creator><creator>Field, Linda M</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20100511</creationdate><title>Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function</title><author>Stanczyk, Nina M ; Brookfield, John F.Y ; Ignell, Rickard ; Logan, James G ; Field, Linda M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-1b645677335c3cbe108d15a122c16f1b576da1fac65248d24e7e9c5046c38c5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aedes - drug effects</topic><topic>Aedes - genetics</topic><topic>Aedes - ultrastructure</topic><topic>Aedes aegypti</topic><topic>Animal behavior</topic><topic>Animal populations</topic><topic>Animal Structures - drug effects</topic><topic>Animal Structures - physiology</topic><topic>Animal Structures - ultrastructure</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>behavioral repellency</topic><topic>Behavioral Sciences Biology</topic><topic>Biological Sciences</topic><topic>Crosses, Genetic</topic><topic>deet</topic><topic>DEET - pharmacology</topic><topic>electroantennography</topic><topic>electrophysiology</topic><topic>Etologi</topic><topic>Female</topic><topic>Female animals</topic><topic>females</topic><topic>Genetics</topic><topic>heritability</topic><topic>Indoles</topic><topic>inheritance (genetics)</topic><topic>insect behavior</topic><topic>Insect pests</topic><topic>Insecticide Resistance - drug effects</topic><topic>Insecticides</topic><topic>line differences</topic><topic>Male</topic><topic>Mosquitoes</topic><topic>Mosquitos</topic><topic>Neurons</topic><topic>neurophysiology</topic><topic>Odors</topic><topic>olfactory receptor neurons</topic><topic>Olfactory Receptor Neurons - drug effects</topic><topic>Olfactory Receptor Neurons - metabolism</topic><topic>olfactory receptors</topic><topic>Personality traits</topic><topic>Phenotypic traits</topic><topic>Quantitative Trait, Heritable</topic><topic>Receptors</topic><topic>Resistance to control</topic><topic>Selection, Genetic</topic><topic>Sensilla</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stanczyk, Nina M</creatorcontrib><creatorcontrib>Brookfield, John F.Y</creatorcontrib><creatorcontrib>Ignell, Rickard</creatorcontrib><creatorcontrib>Logan, James G</creatorcontrib><creatorcontrib>Field, Linda M</creatorcontrib><creatorcontrib>Sveriges lantbruksuniversitet</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stanczyk, Nina M</au><au>Brookfield, John F.Y</au><au>Ignell, Rickard</au><au>Logan, James G</au><au>Field, Linda M</au><aucorp>Sveriges lantbruksuniversitet</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2010-05-11</date><risdate>2010</risdate><volume>107</volume><issue>19</issue><spage>8575</spage><epage>8580</epage><pages>8575-8580</pages><issn>0027-8424</issn><issn>1091-6490</issn><eissn>1091-6490</eissn><abstract>N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that were insensitive to DEET, and the selection of either sensitive or insensitive groups of females with males of unknown sensitivity over several generations resulted in two populations with different proportions of insensitive females. Crossing experiments showed the "insensitivity" trait to be dominant. Electroantennography showed a reduced response to DEET in the selected insensitive line compared with the selected sensitive line, and single sensillum recordings identified DEET-sensitive sensilla that were nonresponders in the insensitive line. This study suggests that behavioral insensitivity to DEET in A. aegypti is a genetically determined dominant trait and resides in changes in sensillum function.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>20439757</pmid><doi>10.1073/pnas.1001313107</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0027-8424 |
ispartof | Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (19), p.8575-8580 |
issn | 0027-8424 1091-6490 1091-6490 |
language | eng |
recordid | cdi_pubmed_primary_20439757 |
source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
subjects | Aedes - drug effects Aedes - genetics Aedes - ultrastructure Aedes aegypti Animal behavior Animal populations Animal Structures - drug effects Animal Structures - physiology Animal Structures - ultrastructure Animals Behavior, Animal - drug effects behavioral repellency Behavioral Sciences Biology Biological Sciences Crosses, Genetic deet DEET - pharmacology electroantennography electrophysiology Etologi Female Female animals females Genetics heritability Indoles inheritance (genetics) insect behavior Insect pests Insecticide Resistance - drug effects Insecticides line differences Male Mosquitoes Mosquitos Neurons neurophysiology Odors olfactory receptor neurons Olfactory Receptor Neurons - drug effects Olfactory Receptor Neurons - metabolism olfactory receptors Personality traits Phenotypic traits Quantitative Trait, Heritable Receptors Resistance to control Selection, Genetic Sensilla Studies |
title | Behavioral insensitivity to DEET in Aedes aegypti is a genetically determined trait residing in changes in sensillum function |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T04%3A51%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Behavioral%20insensitivity%20to%20DEET%20in%20Aedes%20aegypti%20is%20a%20genetically%20determined%20trait%20residing%20in%20changes%20in%20sensillum%20function&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Stanczyk,%20Nina%20M&rft.aucorp=Sveriges%20lantbruksuniversitet&rft.date=2010-05-11&rft.volume=107&rft.issue=19&rft.spage=8575&rft.epage=8580&rft.pages=8575-8580&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.1001313107&rft_dat=%3Cjstor_pubme%3E25681458%3C/jstor_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201316425&rft_id=info:pmid/20439757&rft_jstor_id=25681458&rfr_iscdi=true |