Phase II study of 13-cis-retinoic acid in pediatric patients with acute nonlymphocytic leukemia : a pediatric oncology group study

Forty-one patients with refractory acute non-lymphocytic leukemia (ANLL) in relapse were treated with 13-cis-retinoic acid (cRA) as salvage therapy. The cRA was given as a single oral dose of 100 mg/m2/day for 4 weeks. One patient achieved a complete remission and two patients achieved a partial rem...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of immunotherapy 1991-04, Vol.10 (2), p.77-83
Hauptverfasser:	BELL, B. A, FINDLEY, H. W, KRISCHER, J, WHITEHEAD, V. M, HOLBROOK, T, HAGGARD, M. E, KONRAD, P. N, HENSLEY, M, RAGAB, A. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic agents Biological and medical sciences Cell Division Chemotherapy Child Child, Preschool Drug Evaluation Female Humans Infant Isotretinoin - administration & dosage Isotretinoin - adverse effects Isotretinoin - therapeutic use Leukemia, Megakaryoblastic, Acute - drug therapy Leukemia, Megakaryoblastic, Acute - pathology Leukemia, Monocytic, Acute - drug therapy Leukemia, Monocytic, Acute - pathology Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - pathology Leukemia, Myelomonocytic, Acute - drug therapy Leukemia, Myelomonocytic, Acute - pathology Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - pathology Male Medical sciences Pharmacology. Drug treatments Remission Induction Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Forty-one patients with refractory acute non-lymphocytic leukemia (ANLL) in relapse were treated with 13-cis-retinoic acid (cRA) as salvage therapy. The cRA was given as a single oral dose of 100 mg/m2/day for 4 weeks. One patient achieved a complete remission and two patients achieved a partial remission with reduction of the bone marrow blast count from 40 to 20% after the first course. We recommend further study of cRA in combination with other agents in the treatment of ANLL in children.
ISSN:	1053-8550 1524-9557 2331-3668
DOI:	10.1097/00002371-199104000-00001