Novel phenolic glycosides, adenophorasides A–E, from Adenophora roots

Five novel phenolic glycosides, adenophorasides A ( 1 ), B ( 2 ), C ( 3 ), D ( 4 ), and E ( 5 ), were isolated from commercial Adenophora roots, together with vanilloloside ( 6 ), 3,4-dimethoxybenzyl alcohol 7- O -β- d -glucopyranoside ( 7 ), and lobetyolin ( 8 ). The structures of the new compounds ( 1 – 5 ) were characterized as 4-hydroxy-3-methoxyphenylacetonitrile 4- O -β- d -glucopyranoside ( 1 ), 4-hydroxy-3-methoxyphenylacetonitrile 4- O -β- d -glucopyranosyl-(1→6)-β- d -glucopyranoside ( 2 ), 4-hydroxy-3-methoxyphenylacetonitrile 4- O -α- l -rhamnopyranosyl-(1→6)-β- d -glucopyranoside ( 3 ), 4-hydroxyphenylacetonitrile 4- O -β- d -glucopyranosyl-(1→6)-β- d -glucopyranoside ( 4 ), and 4-hydroxy-3-methoxybenzyl alcohol 4- O -β- d -glucopyranosyl-(1→6)-β- d -glucopyranoside ( 5 ), respectively, by means of spectroscopic and chemical analyses.