Search for Cellular Phosphorylation Products of D-Allose

Search for Cellular Phosphorylation Products of D-Allose

The all-cis hexose D-allose, fed to hamster fibroblast cultures over 14-20 hr, brings about a striking down-regulation of hexose transport. This down-regulation by allose is inhibited by 2,4-dinitrophenol. By using D-[14C]allose and thin-layer chromatography, two types of products accumulated that h...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1991-02, Vol.88 (4), p.1504-1505
Hauptverfasser: Ullrey, Donna B., Kalckar, Herman M.
Format: Artikel
Sprache:eng
Schlagworte:
550501 - Metabolism- Tracer Techniques
ANIMAL CELLS
ANIMALS
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
Biotransformation
CARBOHYDRATES
CARBON 14 COMPOUNDS
Carbon Radioisotopes
Cell extracts
Cell Line
Cell physiology
CHEMICAL REACTIONS
CHROMATOGRAPHY
Chromatography, Thin Layer
CONNECTIVE TISSUE CELLS
Cricetinae
Cricetulus
Down regulation
Ethanol
FIBROBLASTS
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
HAMSTERS
HEXOSES
ISOTOPE APPLICATIONS
Kinetics
LABELLED COMPOUNDS
Lung
MAMMALS
Membrane and intracellular transports
MEMBRANE TRANSPORT
METABOLISM
Molecular and cellular biology
MONOSACCHARIDES
ORGANIC COMPOUNDS
Phosphatases
Phosphates
PHOSPHORYLATION
Radioisotope Dilution Technique
RODENTS
SACCHARIDES
SEPARATION PROCESSES
SOMATIC CELLS
THIN-LAYER CHROMATOGRAPHY
TRACER TECHNIQUES
VERTEBRATES
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Zusammenfassung:The all-cis hexose D-allose, fed to hamster fibroblast cultures over 14-20 hr, brings about a striking down-regulation of hexose transport. This down-regulation by allose is inhibited by 2,4-dinitrophenol. By using D-[14C]allose and thin-layer chromatography, two types of products accumulated that have been identified as allose and allose phosphate. We suspect that allose phosphate might be the down-regulator.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.88.4.1504