A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions
contains motoneurons that provide the exclusive motor nerve supply to the tongue. In addition to voluntary tongue movements, tongue muscles rhythmically contract during a wide range of physiological activities, such as respiration, swallowing, chewing and sucking. Hypoglossal motoneurons are destroy...
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| Veröffentlicht in: | Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2009-09, Vol.364 (1529), p.2493-2500 |
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| container_title | Philosophical transactions of the Royal Society of London. Series B. Biological sciences |
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| creator | Cifra, Alessandra Nani, Francesca Sharifullina, Elina Nistri, Andrea |
| description | contains motoneurons that provide the exclusive motor nerve supply to the tongue. In addition to voluntary tongue movements,
tongue muscles rhythmically contract during a wide range of physiological activities, such as respiration, swallowing, chewing
and sucking. Hypoglossal motoneurons are destroyed early in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative
disease often associated with a deficit in the transport system of the neurotransmitter glutamate. |
| doi_str_mv | 10.1098/rstb.2009.0071 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmed_primary_19651651</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>40486024</jstor_id><sourcerecordid>40486024</sourcerecordid><originalsourceid>FETCH-LOGICAL-c691t-76b9910392adffc57ad269871114e841a07f3db45f05ef43e3e425c5e755ec2f3</originalsourceid><addsrcrecordid>eNp9Ul2L1DAULaK44-qrb0r-QMd8Ns2LuLv4BSuijiv4Eto0mWa205QkXa2_3sx2GB3EhUBIzjn33nOSLHuK4BJBUb7wIdZLDKFYQsjRvWyBKEc5FhzezxZQFDgvKSlOskchbGCiMU4fZidIFAyltcj8GfB60D466zVwBvh2iu3WKlCPqbbt12DwrhmVbkA9gXYa3LpzIVQd2Lroej161wdgezC0U7Cuc2urElj1DRiq2B4ulOsbG20iP84emKoL-sl-P82-vnm9uniXX358-_7i7DJXhUAx50UtBIJE4KoxRjFeNbgQJUcIUV1SVEFuSFNTZiDThhJNNMVMMc0Z0wobcpq9nOsOY73VjdJ99FUnB2-3lZ-kq6w8RnrbyrW7kbhM0SCRCiznAsonx16bgxZBuUtf7tKXu_TlLv0keP53xz_0fdyJcD0TvJuSdaesjpPcuNH36Sg_f1md35CCWsRwKlkSBClitJC_7DD3SqC0IYxa3lKO-_87Drmr239NPJtVmxCdP3igkJYFxDTh-YzbEPXPA175a1lwwpm8Kqn8tvqAPhFxJb8nPpr5rV23P9Ivk0fjpMOwN3ZrCVNBkubVnZrdxOlDxfRwx0ppxi49cWPIb5XP-3E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><creator>Cifra, Alessandra ; Nani, Francesca ; Sharifullina, Elina ; Nistri, Andrea</creator><creatorcontrib>Cifra, Alessandra ; Nani, Francesca ; Sharifullina, Elina ; Nistri, Andrea</creatorcontrib><description>contains motoneurons that provide the exclusive motor nerve supply to the tongue. In addition to voluntary tongue movements,
tongue muscles rhythmically contract during a wide range of physiological activities, such as respiration, swallowing, chewing
and sucking. Hypoglossal motoneurons are destroyed early in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative
disease often associated with a deficit in the transport system of the neurotransmitter glutamate.</description><description>-induced oxidative stress strongly increases motoneuron excitability without eliciting bursting. Riluzole (the only drug currently
licensed for the treatment of ALS) suppresses bursting of hypoglossal motoneurons caused by blockage of glutamate uptake and
limits motoneuron death. These findings highlight how different patterns of electrical oscillations of brainstem motoneurons
underpin not only certain physiological activities, but also motoneuron death induced by glutamate transporter impairment.</description><description>The present study shows how periodic electrical discharges of motoneurons are mainly produced by a neuronal network that drives
them into bursting mode via glutamatergic excitatory synapses. Burst activity is, however, modulated by the intrinsic properties
of motoneurons that collectively synchronize their discharges via gap junctions to create ‘group bursters’. When glial uptake
of glutamate is blocked, a distinct form of pathological bursting spontaneously emerges and leads to motoneuron death. Conversely,
H</description><description>nucleus hypoglossus</description><description>The brainstem</description><identifier>ISSN: 0962-8436</identifier><identifier>EISSN: 1471-2970</identifier><identifier>DOI: 10.1098/rstb.2009.0071</identifier><identifier>PMID: 19651651</identifier><language>eng</language><publisher>England: The Royal Society</publisher><subject>Action Potentials - drug effects ; Action Potentials - physiology ; Amyotrophic Lateral Sclerosis ; Animals ; Brain stem ; Brain Stem - physiology ; Brainstem ; Depolarization ; Electric current ; Electrical couplings ; Glutamate Uptake ; Glutamic Acid - metabolism ; Humans ; Hydrogen Peroxide ; Hydrogen Peroxide - toxicity ; Hypoglossal Nerve - physiology ; Membrane potential ; Mice ; Models, Biological ; Motor Neurons - drug effects ; Motor Neurons - physiology ; Neurodegenerative Diseases - etiology ; Neurodegenerative Diseases - physiopathology ; Neurons ; Neuroprotective Agents - pharmacology ; Neuroscience ; Oscillation ; Oxidative Stress ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Periodicity ; Pharmacology ; Riluzole - pharmacology ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology ; Tongue - innervation ; Tongue - physiology</subject><ispartof>Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2009-09, Vol.364 (1529), p.2493-2500</ispartof><rights>Copyright 2009 The Royal Society</rights><rights>2009 The Royal Society</rights><rights>2009 The Royal Society 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-76b9910392adffc57ad269871114e841a07f3db45f05ef43e3e425c5e755ec2f3</citedby><cites>FETCH-LOGICAL-c691t-76b9910392adffc57ad269871114e841a07f3db45f05ef43e3e425c5e755ec2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40486024$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40486024$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27923,27924,53790,53792,58016,58249</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19651651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cifra, Alessandra</creatorcontrib><creatorcontrib>Nani, Francesca</creatorcontrib><creatorcontrib>Sharifullina, Elina</creatorcontrib><creatorcontrib>Nistri, Andrea</creatorcontrib><title>A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions</title><title>Philosophical transactions of the Royal Society of London. Series B. Biological sciences</title><addtitle>Phil. Trans. R. Soc. B</addtitle><addtitle>Phil. Trans. R. Soc. B</addtitle><description>contains motoneurons that provide the exclusive motor nerve supply to the tongue. In addition to voluntary tongue movements,
tongue muscles rhythmically contract during a wide range of physiological activities, such as respiration, swallowing, chewing
and sucking. Hypoglossal motoneurons are destroyed early in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative
disease often associated with a deficit in the transport system of the neurotransmitter glutamate.</description><description>-induced oxidative stress strongly increases motoneuron excitability without eliciting bursting. Riluzole (the only drug currently
licensed for the treatment of ALS) suppresses bursting of hypoglossal motoneurons caused by blockage of glutamate uptake and
limits motoneuron death. These findings highlight how different patterns of electrical oscillations of brainstem motoneurons
underpin not only certain physiological activities, but also motoneuron death induced by glutamate transporter impairment.</description><description>The present study shows how periodic electrical discharges of motoneurons are mainly produced by a neuronal network that drives
them into bursting mode via glutamatergic excitatory synapses. Burst activity is, however, modulated by the intrinsic properties
of motoneurons that collectively synchronize their discharges via gap junctions to create ‘group bursters’. When glial uptake
of glutamate is blocked, a distinct form of pathological bursting spontaneously emerges and leads to motoneuron death. Conversely,
H</description><description>nucleus hypoglossus</description><description>The brainstem</description><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Amyotrophic Lateral Sclerosis</subject><subject>Animals</subject><subject>Brain stem</subject><subject>Brain Stem - physiology</subject><subject>Brainstem</subject><subject>Depolarization</subject><subject>Electric current</subject><subject>Electrical couplings</subject><subject>Glutamate Uptake</subject><subject>Glutamic Acid - metabolism</subject><subject>Humans</subject><subject>Hydrogen Peroxide</subject><subject>Hydrogen Peroxide - toxicity</subject><subject>Hypoglossal Nerve - physiology</subject><subject>Membrane potential</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Motor Neurons - drug effects</subject><subject>Motor Neurons - physiology</subject><subject>Neurodegenerative Diseases - etiology</subject><subject>Neurodegenerative Diseases - physiopathology</subject><subject>Neurons</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroscience</subject><subject>Oscillation</subject><subject>Oxidative Stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Periodicity</subject><subject>Pharmacology</subject><subject>Riluzole - pharmacology</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><subject>Tongue - innervation</subject><subject>Tongue - physiology</subject><issn>0962-8436</issn><issn>1471-2970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Ul2L1DAULaK44-qrb0r-QMd8Ns2LuLv4BSuijiv4Eto0mWa205QkXa2_3sx2GB3EhUBIzjn33nOSLHuK4BJBUb7wIdZLDKFYQsjRvWyBKEc5FhzezxZQFDgvKSlOskchbGCiMU4fZidIFAyltcj8GfB60D466zVwBvh2iu3WKlCPqbbt12DwrhmVbkA9gXYa3LpzIVQd2Lroej161wdgezC0U7Cuc2urElj1DRiq2B4ulOsbG20iP84emKoL-sl-P82-vnm9uniXX358-_7i7DJXhUAx50UtBIJE4KoxRjFeNbgQJUcIUV1SVEFuSFNTZiDThhJNNMVMMc0Z0wobcpq9nOsOY73VjdJ99FUnB2-3lZ-kq6w8RnrbyrW7kbhM0SCRCiznAsonx16bgxZBuUtf7tKXu_TlLv0keP53xz_0fdyJcD0TvJuSdaesjpPcuNH36Sg_f1md35CCWsRwKlkSBClitJC_7DD3SqC0IYxa3lKO-_87Drmr239NPJtVmxCdP3igkJYFxDTh-YzbEPXPA175a1lwwpm8Kqn8tvqAPhFxJb8nPpr5rV23P9Ivk0fjpMOwN3ZrCVNBkubVnZrdxOlDxfRwx0ppxi49cWPIb5XP-3E</recordid><startdate>20090912</startdate><enddate>20090912</enddate><creator>Cifra, Alessandra</creator><creator>Nani, Francesca</creator><creator>Sharifullina, Elina</creator><creator>Nistri, Andrea</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20090912</creationdate><title>A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions</title><author>Cifra, Alessandra ; Nani, Francesca ; Sharifullina, Elina ; Nistri, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-76b9910392adffc57ad269871114e841a07f3db45f05ef43e3e425c5e755ec2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Amyotrophic Lateral Sclerosis</topic><topic>Animals</topic><topic>Brain stem</topic><topic>Brain Stem - physiology</topic><topic>Brainstem</topic><topic>Depolarization</topic><topic>Electric current</topic><topic>Electrical couplings</topic><topic>Glutamate Uptake</topic><topic>Glutamic Acid - metabolism</topic><topic>Humans</topic><topic>Hydrogen Peroxide</topic><topic>Hydrogen Peroxide - toxicity</topic><topic>Hypoglossal Nerve - physiology</topic><topic>Membrane potential</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Motor Neurons - drug effects</topic><topic>Motor Neurons - physiology</topic><topic>Neurodegenerative Diseases - etiology</topic><topic>Neurodegenerative Diseases - physiopathology</topic><topic>Neurons</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroscience</topic><topic>Oscillation</topic><topic>Oxidative Stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Periodicity</topic><topic>Pharmacology</topic><topic>Riluzole - pharmacology</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><topic>Tongue - innervation</topic><topic>Tongue - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cifra, Alessandra</creatorcontrib><creatorcontrib>Nani, Francesca</creatorcontrib><creatorcontrib>Sharifullina, Elina</creatorcontrib><creatorcontrib>Nistri, Andrea</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Philosophical transactions of the Royal Society of London. Series B. Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cifra, Alessandra</au><au>Nani, Francesca</au><au>Sharifullina, Elina</au><au>Nistri, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions</atitle><jtitle>Philosophical transactions of the Royal Society of London. Series B. Biological sciences</jtitle><stitle>Phil. Trans. R. Soc. B</stitle><addtitle>Phil. Trans. R. Soc. B</addtitle><date>2009-09-12</date><risdate>2009</risdate><volume>364</volume><issue>1529</issue><spage>2493</spage><epage>2500</epage><pages>2493-2500</pages><issn>0962-8436</issn><eissn>1471-2970</eissn><abstract>contains motoneurons that provide the exclusive motor nerve supply to the tongue. In addition to voluntary tongue movements,
tongue muscles rhythmically contract during a wide range of physiological activities, such as respiration, swallowing, chewing
and sucking. Hypoglossal motoneurons are destroyed early in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative
disease often associated with a deficit in the transport system of the neurotransmitter glutamate.</abstract><abstract>-induced oxidative stress strongly increases motoneuron excitability without eliciting bursting. Riluzole (the only drug currently
licensed for the treatment of ALS) suppresses bursting of hypoglossal motoneurons caused by blockage of glutamate uptake and
limits motoneuron death. These findings highlight how different patterns of electrical oscillations of brainstem motoneurons
underpin not only certain physiological activities, but also motoneuron death induced by glutamate transporter impairment.</abstract><abstract>The present study shows how periodic electrical discharges of motoneurons are mainly produced by a neuronal network that drives
them into bursting mode via glutamatergic excitatory synapses. Burst activity is, however, modulated by the intrinsic properties
of motoneurons that collectively synchronize their discharges via gap junctions to create ‘group bursters’. When glial uptake
of glutamate is blocked, a distinct form of pathological bursting spontaneously emerges and leads to motoneuron death. Conversely,
H</abstract><abstract>nucleus hypoglossus</abstract><abstract>The brainstem</abstract><cop>England</cop><pub>The Royal Society</pub><pmid>19651651</pmid><doi>10.1098/rstb.2009.0071</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0962-8436 |
| ispartof | Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2009-09, Vol.364 (1529), p.2493-2500 |
| issn | 0962-8436 1471-2970 |
| language | eng |
| recordid | cdi_pubmed_primary_19651651 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central |
| subjects | Action Potentials - drug effects Action Potentials - physiology Amyotrophic Lateral Sclerosis Animals Brain stem Brain Stem - physiology Brainstem Depolarization Electric current Electrical couplings Glutamate Uptake Glutamic Acid - metabolism Humans Hydrogen Peroxide Hydrogen Peroxide - toxicity Hypoglossal Nerve - physiology Membrane potential Mice Models, Biological Motor Neurons - drug effects Motor Neurons - physiology Neurodegenerative Diseases - etiology Neurodegenerative Diseases - physiopathology Neurons Neuroprotective Agents - pharmacology Neuroscience Oscillation Oxidative Stress Oxidative Stress - drug effects Oxidative Stress - physiology Periodicity Pharmacology Riluzole - pharmacology Synaptic Transmission - drug effects Synaptic Transmission - physiology Tongue - innervation Tongue - physiology |
| title | A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions |
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