A repertoire of rhythmic bursting produced by hypoglossal motoneurons in physiological and pathological conditions

contains motoneurons that provide the exclusive motor nerve supply to the tongue. In addition to voluntary tongue movements, tongue muscles rhythmically contract during a wide range of physiological activities, such as respiration, swallowing, chewing and sucking. Hypoglossal motoneurons are destroy...

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Veröffentlicht in:	Philosophical transactions of the Royal Society of London. Series B. Biological sciences 2009-09, Vol.364 (1529), p.2493-2500
Hauptverfasser:	Cifra, Alessandra, Nani, Francesca, Sharifullina, Elina, Nistri, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Amyotrophic Lateral Sclerosis Animals Brain stem Brain Stem - physiology Brainstem Depolarization Electric current Electrical couplings Glutamate Uptake Glutamic Acid - metabolism Humans Hydrogen Peroxide Hydrogen Peroxide - toxicity Hypoglossal Nerve - physiology Membrane potential Mice Models, Biological Motor Neurons - drug effects Motor Neurons - physiology Neurodegenerative Diseases - etiology Neurodegenerative Diseases - physiopathology Neurons Neuroprotective Agents - pharmacology Neuroscience Oscillation Oxidative Stress Oxidative Stress - drug effects Oxidative Stress - physiology Periodicity Pharmacology Riluzole - pharmacology Synaptic Transmission - drug effects Synaptic Transmission - physiology Tongue - innervation Tongue - physiology
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Beschreibung
Zusammenfassung:	contains motoneurons that provide the exclusive motor nerve supply to the tongue. In addition to voluntary tongue movements, tongue muscles rhythmically contract during a wide range of physiological activities, such as respiration, swallowing, chewing and sucking. Hypoglossal motoneurons are destroyed early in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease often associated with a deficit in the transport system of the neurotransmitter glutamate.
ISSN:	0962-8436 1471-2970
DOI:	10.1098/rstb.2009.0071