Aliphatic polyester terpolymers for stent coating and drug elution: Effect of polymer composition on drug solubility and release

Ring-opening terpolymerization of L-lactide (LA), -caprolactone (CL), and glycolide (GA) was performed in the presence of tin (II) 2-ethylhexanoate at 170°C. Random terpolyesters with weight-average molecular weight up to 130,000 g/mol were obtained. These terpolyesters, especially those with LA:CL:...

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Veröffentlicht in:	Drug delivery 2009-08, Vol.16 (6), p.304-311
Hauptverfasser:	Chan-Seng, Delphine, Ranganathan, T., Zhang, Xiongfei, Tang, Yiwen, Lin, Qing, Kleiner, Lothar, Emrick, Todd
Format:	Artikel
Sprache:	eng
Schlagworte:	coating Drug Delivery Systems - methods drug release Drug-Eluting Stents everolimus Polyester Polyesters - chemistry Polyesters - pharmacokinetics Polymers - chemistry Polymers - pharmacokinetics Solubility stent
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