Aliphatic polyester terpolymers for stent coating and drug elution: Effect of polymer composition on drug solubility and release

Ring-opening terpolymerization of L-lactide (LA), -caprolactone (CL), and glycolide (GA) was performed in the presence of tin (II) 2-ethylhexanoate at 170°C. Random terpolyesters with weight-average molecular weight up to 130,000 g/mol were obtained. These terpolyesters, especially those with LA:CL:...

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Veröffentlicht in:	Drug delivery 2009-08, Vol.16 (6), p.304-311
Hauptverfasser:	Chan-Seng, Delphine, Ranganathan, T., Zhang, Xiongfei, Tang, Yiwen, Lin, Qing, Kleiner, Lothar, Emrick, Todd
Format:	Artikel
Sprache:	eng
Schlagworte:	coating Drug Delivery Systems - methods drug release Drug-Eluting Stents everolimus Polyester Polyesters - chemistry Polyesters - pharmacokinetics Polymers - chemistry Polymers - pharmacokinetics Solubility stent
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container_title	Drug delivery
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creator	Chan-Seng, Delphine Ranganathan, T. Zhang, Xiongfei Tang, Yiwen Lin, Qing Kleiner, Lothar Emrick, Todd
description	Ring-opening terpolymerization of L-lactide (LA), -caprolactone (CL), and glycolide (GA) was performed in the presence of tin (II) 2-ethylhexanoate at 170°C. Random terpolyesters with weight-average molecular weight up to 130,000 g/mol were obtained. These terpolyesters, especially those with LA:CL:GA composition of 3:1:1, provided good coating integrity following spraying onto bare metal stents. The semi-synthetic macrolide immunosuppressant, everolimus, was incorporated into the terpolyester coating, and its release from the stent was evaluated. Unlike PLLA homopolymers, which are immiscible with the drug and non-optimal for controlled release, these terpolymers gave excellent control in a screening study, by tuning terpolymer molecular weight, relative monomer ratio, and drug-to-polymer ratio. Adjusting the polymer properties to improve drug solubility (or miscibility) in the polymer coating was found beneficial to the release profile.
doi_str_mv	10.1080/10717540902999653
format	Article
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subjects	coating Drug Delivery Systems - methods drug release Drug-Eluting Stents everolimus Polyester Polyesters - chemistry Polyesters - pharmacokinetics Polymers - chemistry Polymers - pharmacokinetics Solubility stent
title	Aliphatic polyester terpolymers for stent coating and drug elution: Effect of polymer composition on drug solubility and release
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