Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients -- impact of cryopreservation with dimethylsulfoxide

Dimethylsulfoxide (DMSO) is the most frequently used agent for hematopoietic cell (HC) graft cryopreservation. This study aimed to monitor blood pressure and heart rate (HR) during HC graft infusion and assess the impact of cryopreservation with DMSO. 153 HC graft infusions in 153 consecutive hemato...

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Veröffentlicht in:	Experimental oncology 2009-06, Vol.31 (2), p.121
Hauptverfasser:	Horacek, J M, Jebavy, L, Jakl, M, Zak, P, Mericka, P, Maly, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Pressure - drug effects Cardiovascular System - drug effects Cryopreservation - methods Cryoprotective Agents - adverse effects Dimethyl Sulfoxide - adverse effects Female Heart Rate - drug effects Hematologic Neoplasms - drug therapy Hematopoietic Stem Cell Transplantation - adverse effects Humans Male Middle Aged
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Zusammenfassung:	Dimethylsulfoxide (DMSO) is the most frequently used agent for hematopoietic cell (HC) graft cryopreservation. This study aimed to monitor blood pressure and heart rate (HR) during HC graft infusion and assess the impact of cryopreservation with DMSO. 153 HC graft infusions in 153 consecutive hematological patients (mean age 49.1 -/+ 12.6 years; 80 males) were evaluated. Cryopreservation with DMSO was used in 133 grafts (DMSO group). Twenty grafts were infused directly without cryopreservation (control group). Systolic blood pressure (SBP), diastolic blood pressure (DBP) and HR were measured immediately before and after HC graft infusion. SBP and DBP increased significantly after graft infusions cryopreserved with DMSO ( p
ISSN:	1812-9269