Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists
A gamma-carboline series of cysLT(1) receptor antagonists has been prepared. Some of the compounds show good potencies both, in vitro and in vivo, compared to the standard compounds.
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Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (15), p.4299 |
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Hauptverfasser: | , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A gamma-carboline series of cysLT(1) receptor antagonists has been prepared. Some of the compounds show good potencies both, in vitro and in vivo, compared to the standard compounds. |
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ISSN: | 1464-3405 |
DOI: | 10.1016/j.bmcl.2009.05.094 |