Synthesis and structure-activity relationships of gamma-carboline derivatives as potent and selective cysLT(1) antagonists

A gamma-carboline series of cysLT(1) receptor antagonists has been prepared. Some of the compounds show good potencies both, in vitro and in vivo, compared to the standard compounds.

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (15), p.4299
Hauptverfasser: Bonjoch, Josep, Diaba, Faïza, Pagès, Lluís, Pérez, Daniel, Soca, Lidia, Miralpeix, Montserrat, Vilella, Dolors, Anton, Paquita, Puig, Carles
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Sprache:eng
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Zusammenfassung:A gamma-carboline series of cysLT(1) receptor antagonists has been prepared. Some of the compounds show good potencies both, in vitro and in vivo, compared to the standard compounds.
ISSN:1464-3405
DOI:10.1016/j.bmcl.2009.05.094