Down-regulation of cerebellar 5-HT(2C) receptors in pilocarpine-induced epilepsy in rats: therapeutic role of Bacopa monnieri extract

Epilepsy is a syndrome of episodic brain dysfunction characterized by recurrent unpredictable, spontaneous seizures. Cerebellar dysfunction is a recognized complication of temporal lobe epilepsy and it is associated with seizure generation, motor deficits and memory impairment. Serotonin is known to...

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Veröffentlicht in:	Journal of the neurological sciences 2009-09, Vol.284 (1-2), p.124
Hauptverfasser:	Krishnakumar, Amee, Abraham, Pretty Mary, Paul, Jes, Paulose, C S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - isolation & purification Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Ataxia - drug therapy Ataxia - etiology Bacopa - chemistry Carbamazepine - pharmacology Carbamazepine - therapeutic use Cerebellum - drug effects Cerebellum - metabolism Down-Regulation - drug effects Drug Evaluation, Preclinical Epilepsy - chemically induced Epilepsy - drug therapy Epilepsy - genetics Epilepsy - metabolism Male Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Phytotherapy Pilocarpine - toxicity Plant Extracts - pharmacology Plant Extracts - therapeutic use Protein Binding - drug effects Rats Rats, Wistar Receptor, Serotonin, 5-HT2C - genetics Receptor, Serotonin, 5-HT2C - metabolism Serotonin - metabolism Serotonin Receptor Agonists - isolation & purification Serotonin Receptor Agonists - pharmacology Serotonin Receptor Agonists - therapeutic use
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Zusammenfassung:	Epilepsy is a syndrome of episodic brain dysfunction characterized by recurrent unpredictable, spontaneous seizures. Cerebellar dysfunction is a recognized complication of temporal lobe epilepsy and it is associated with seizure generation, motor deficits and memory impairment. Serotonin is known to exert a modulatory action on cerebellar function through 5HT(2C) receptors. 5-HT(2C) receptors are novel targets for developing anti-convulsant drugs. In the present study, we investigated the changes in the 5-HT(2C) receptors binding and gene expression in the cerebellum of control, epileptic and Bacopa monnieri treated epileptic rats. There was a significant down regulation of the 5-HT content (p
ISSN:	1878-5883
DOI:	10.1016/j.jns.2009.04.032