Use of MDRD equation to detect occult renal failure and reduce the risk of digitalis overdose

Digoxin overdose is closely related to Chronic Kidney Disease and creatinine dosage adjustment is usually needed. Our goal was to assess the advantages of serum creatinine and the MDRD equation to detect hidden renal insufficiency to reduce the overdose Digital risk. We describe all digoxin samples...

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Veröffentlicht in:	Nefrología 2009, Vol.29 (2), p.150
Hauptverfasser:	Cepeda Piorno, J, Pobes Martínez de Salinas, A, González García, M E, Fernández Rodríguez, E
Format:	Artikel
Sprache:	spa
Schlagworte:	Aged Aged, 80 and over Algorithms Creatinine - blood Cross-Sectional Studies Digoxin - administration & dosage Digoxin - blood Digoxin - pharmacokinetics Drug Overdose - prevention & control Female Glomerular Filtration Rate Heart Failure - blood Heart Failure - complications Heart Failure - drug therapy Humans Kidney - physiopathology Kidney Failure, Chronic - blood Kidney Failure, Chronic - complications Kidney Failure, Chronic - diagnosis Male Middle Aged ROC Curve
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Zusammenfassung:	Digoxin overdose is closely related to Chronic Kidney Disease and creatinine dosage adjustment is usually needed. Our goal was to assess the advantages of serum creatinine and the MDRD equation to detect hidden renal insufficiency to reduce the overdose Digital risk. We describe all digoxin samples processed and registered in our hospital laboratory database for a year. Patients under 18 years and samples below therapeutic ranges were excluded. Chi square (p
ISSN:	0211-6995
DOI:	10.3265/Nefrologia.2009.29.2.4583.en.full