Postmenopausal bleeding due to cervical involvement with Wegener's granulomatosis

Wegener's granulomatosis (WG) is a rare chronic, relapsing, systemic necrotising vasculitis with typical pathological findings of granulomatous inflammation and pauci-immune vasculitis commonly affecting the upper respiratory tract, lungs and kidneys. Antineutrophil cytoplasmic antibodies play a central role in the pathogenesis of the disease. Vasculitis involves the small- to medium-sized arteries and veins. Here, Maina et al present a case of a 64-year-old woman who is presented in January 2008 with a 3-week history of vaginal bleeding and increasing breathlessness for 2 months. She had a 10-year history of WG with an initial presentation of ear, eye and renal involvement. She underwent laser treatment, dilatation and submucosal steroid injection. Treatment was continued at the local hospital with oral pre-dnisolone and intravenous Rituximab.