Noscapine Inhibits Human Prostate Cancer Progression and Metastasis in a Mouse Model

Noscapine Inhibits Human Prostate Cancer Progression and Metastasis in a Mouse Model

Background: Noscapine, a non-toxic alkaloid and common constituent of cough medicine, stabilises tubulin. It inhibits the growth of several human and murine neoplasms, with no significant toxicity. Its effect on prostate cancer has not been evaluated. Materials and Methods: Noscapine was administere...

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Veröffentlicht in:Anticancer research 2008-11, Vol.28 (6A), p.3701-3704
Hauptverfasser: BARKEN, Israel, GELLER, Jack, ROGOSNITZKY, Moshe
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Body Weight - drug effects
Cell Growth Processes - drug effects
Cell Line, Tumor
Disease Progression
Humans
Male
Medical sciences
Mice
Mice, Nude
Neoplasm Metastasis
Nephrology. Urinary tract diseases
Noscapine - pharmacology
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - pathology
Tumors
Tumors of the urinary system
Urinary tract. Prostate gland
Xenograft Model Antitumor Assays
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Zusammenfassung:Background: Noscapine, a non-toxic alkaloid and common constituent of cough medicine, stabilises tubulin. It inhibits the growth of several human and murine neoplasms, with no significant toxicity. Its effect on prostate cancer has not been evaluated. Materials and Methods: Noscapine was administered orally (300 mg/kg per day) for 56 days to PC3 human prostate cancer-bearing immunodeficient mice (n=10). Immunodeficient control mice (n=10) received only diluent in an identical regimen. Results: Mean total tumour weight was 0.42±0.23 g and 0.97±0.31 g (p
ISSN:0250-7005
1791-7530