Expression and clinical implication of HIF-1alpha and VEGF-C in non-small cell lung cancer

To study the expression and implication of HIF-1alpha and VEGF-C in non-small cell lung cancer (NSCLC) and its relationship with clinical pathological features of NSCLC, immunohistochemical SP was used to detect the expression of HIF-1alpha and VEGF-C proteins in 48 NSCLC tissues and the same para-c...

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Veröffentlicht in:	Journal of Huazhong University of Science and Technology. Medical sciences 2008-12, Vol.28 (6), p.674
Hauptverfasser:	Zuo, Shunqing, Ji, Yanmei, Wang, Jianjun, Guo, Jialong
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Female Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphatic Metastasis - pathology Male Middle Aged Vascular Endothelial Growth Factor C - metabolism
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Zusammenfassung:	To study the expression and implication of HIF-1alpha and VEGF-C in non-small cell lung cancer (NSCLC) and its relationship with clinical pathological features of NSCLC, immunohistochemical SP was used to detect the expression of HIF-1alpha and VEGF-C proteins in 48 NSCLC tissues and the same para-cancerous tissues. The positive rates of HIF-1alpha and VEGF-C were 70.8% (34/48) and 68.8% (33/48) respectively. The expression of HIF-1alpha protein was detected in a significantly greater proportion in NSCLC carcinoma tissues than that in para-cancerous tissues (12.5% and 16.7%, P
ISSN:	1672-0733
DOI:	10.1007/s11596-008-0613-8