Catecholamine uptake, melanization, and oxygen toxicity in Cryptococcus neoformans

Oxygen sensitivity mutations of Cryptococcus neoformans were mapped to three genetic loci. Three oxygen-sensitive mutants had mutations that appeared allelic and exhibited albinism tightly linked to oxygen sensitivity; these three and a fourth exhibited defects in catechol uptake and catechol oxidat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Bacteriology 1991-01, Vol.173 (1), p.401-403
Hauptverfasser:	Jacobson, E.S. (McGuire Veterans Affairs Medical Center, Richmond, VA), Emery, H.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Transport CATECHOLAMINE Catecholamines - metabolism CATECOLAMINAS COMPOSE PHENOLIQUE COMPUESTOS FENOLICOS Crosses, Genetic CRYPTOCOCCUS (CHAMPIGNON) CRYPTOCOCCUS (HONGO) Cryptococcus neoformans - drug effects Cryptococcus neoformans - genetics Cryptococcus neoformans - metabolism FITOTOXICIDAD Genes, Bacterial Genetic Linkage Melanins - biosynthesis Monophenol Monooxygenase - genetics Monophenol Monooxygenase - metabolism MUTACION MUTANT MUTANTES MUTATION OXIGENO Oxygen - pharmacology OXYGENE Phenotype PHYTOTOXICITE PIGMENT PIGMENTOS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Oxygen sensitivity mutations of Cryptococcus neoformans were mapped to three genetic loci. Three oxygen-sensitive mutants had mutations that appeared allelic and exhibited albinism tightly linked to oxygen sensitivity; these three and a fourth exhibited defects in catechol uptake and catechol oxidation to melanin. Catecholamine metabolism appears to protect C. neoformans from oxidants
ISSN:	0021-9193 1098-5530 1067-8832
DOI:	10.1128/jb.173.1.401-403.1991