The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis
Survivin is a crucial node molecule involved in apoptosis, cell division and drug discovery. Up-regulation of survivin in the tissues of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) originated from OSF has already been demonstrated. Survivin Thr34 phosphorylation is involved...
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| Veröffentlicht in: | Oncology reports 2008-11, Vol.20 (5), p.1085-1091 |
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| creator | Zhou, Shanghui Li, Lili Jian, Xinchun Ou, Xinrong Jiang, Haiying Yao, Zhigang Xu, Chunjiao Peng, Jieying |
| description | Survivin is a crucial node molecule involved in apoptosis, cell division and drug discovery. Up-regulation of survivin in the tissues of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) originated from OSF has already been demonstrated. Survivin Thr34 phosphorylation is involved in the inhibition of apoptosis and cell division. To determine the potential involvement of survivin Thr34 phosphorylation in carcinogenesis of OSF, 40 OSFs, 42 OSCCs originated from OSF and 10 normal tissues from surgical specimens were studied. Immunohistochemistry showed that the positive staining rate of the survivin phosphorylation on Thr34 in OSCC originated from OSF group was significantly higher than that in OSF group (P |
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Up-regulation of survivin in the tissues of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) originated from OSF has already been demonstrated. Survivin Thr34 phosphorylation is involved in the inhibition of apoptosis and cell division. To determine the potential involvement of survivin Thr34 phosphorylation in carcinogenesis of OSF, 40 OSFs, 42 OSCCs originated from OSF and 10 normal tissues from surgical specimens were studied. Immunohistochemistry showed that the positive staining rate of the survivin phosphorylation on Thr34 in OSCC originated from OSF group was significantly higher than that in OSF group (P<0.01), and none in the normal oral mucosa specimens. Survivin phosphorylation on Thr34 is predominantly located in the nucleus, which account for its function in apoptosis at cell division. Western blotting analysis showed increasing expression of survivin Thr34 phosphorylation, cyclin B1 and p34cdc2 in carcinogenesis of OSF. Furthermore, p34cdc2-cyclin B1 kinase was confirmed to phosphorylate survivin on Thr34 in carcinogenesis of OSF by immunoprecipitation and immunoblot. These results suggest that the phosphorylation of survivin on Thr34 critically regulate survivin and plays an important role during the malignant transformation of OSF, which will provide an indication to early diagnosis and therapy in carcinogenesis of OSF.</description><identifier>ISSN: 1021-335X</identifier><identifier>EISSN: 1791-2431</identifier><identifier>PMID: 18949405</identifier><language>eng</language><publisher>Athens: S.n.</publisher><subject>Biological and medical sciences ; Blotting, Western ; Carcinoma, Squamous Cell - metabolism ; CDC2 Protein Kinase - metabolism ; Cell Transformation, Neoplastic - metabolism ; Humans ; Immunohistochemistry ; Immunoprecipitation ; Inhibitor of Apoptosis Proteins ; Medical sciences ; Microtubule-Associated Proteins - metabolism ; Mouth Neoplasms - metabolism ; Neoplasm Proteins - metabolism ; Oral Submucous Fibrosis - metabolism ; Otorhinolaryngology. Stomatology ; Phosphorylation ; Precancerous Conditions - metabolism ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Oncology reports, 2008-11, Vol.20 (5), p.1085-1091</ispartof><rights>2008 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20805733$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18949405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Shanghui</creatorcontrib><creatorcontrib>Li, Lili</creatorcontrib><creatorcontrib>Jian, Xinchun</creatorcontrib><creatorcontrib>Ou, Xinrong</creatorcontrib><creatorcontrib>Jiang, Haiying</creatorcontrib><creatorcontrib>Yao, Zhigang</creatorcontrib><creatorcontrib>Xu, Chunjiao</creatorcontrib><creatorcontrib>Peng, Jieying</creatorcontrib><title>The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>Survivin is a crucial node molecule involved in apoptosis, cell division and drug discovery. Up-regulation of survivin in the tissues of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) originated from OSF has already been demonstrated. Survivin Thr34 phosphorylation is involved in the inhibition of apoptosis and cell division. To determine the potential involvement of survivin Thr34 phosphorylation in carcinogenesis of OSF, 40 OSFs, 42 OSCCs originated from OSF and 10 normal tissues from surgical specimens were studied. Immunohistochemistry showed that the positive staining rate of the survivin phosphorylation on Thr34 in OSCC originated from OSF group was significantly higher than that in OSF group (P<0.01), and none in the normal oral mucosa specimens. Survivin phosphorylation on Thr34 is predominantly located in the nucleus, which account for its function in apoptosis at cell division. Western blotting analysis showed increasing expression of survivin Thr34 phosphorylation, cyclin B1 and p34cdc2 in carcinogenesis of OSF. Furthermore, p34cdc2-cyclin B1 kinase was confirmed to phosphorylate survivin on Thr34 in carcinogenesis of OSF by immunoprecipitation and immunoblot. These results suggest that the phosphorylation of survivin on Thr34 critically regulate survivin and plays an important role during the malignant transformation of OSF, which will provide an indication to early diagnosis and therapy in carcinogenesis of OSF.</description><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>CDC2 Protein Kinase - metabolism</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunoprecipitation</subject><subject>Inhibitor of Apoptosis Proteins</subject><subject>Medical sciences</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Oral Submucous Fibrosis - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Phosphorylation</subject><subject>Precancerous Conditions - metabolism</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1021-335X</issn><issn>1791-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j09LAzEQxYMotla_guTicWGSSTaboxT_QcHLHrxIySYbG9lulsQt9NsbsXoY3jDzm8ebM7JkSrOKC2TnpQfOKkT5tiBXOX8CcAW1viQL1mihBcgleW93PZ12MZdKx8F8hTjS6Gme0yEcwkjbXUJBuyOdUFhnOS0za5INY_zoxz6H_IPHZIZy0-1nG-dMfehSLKtrcuHNkPubk65I-_jQrp-rzevTy_p-U02NkJWzHThkJbN3DJRV2ve1k8LWimnJFJrGqAYtaMFlXWvUnivvO0DoHNQeV-T213YqCXq3nVLYm3Tc_r1ZgLsTYLI1g09mtCH_cxwakAoRvwEuuFx9</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Zhou, Shanghui</creator><creator>Li, Lili</creator><creator>Jian, Xinchun</creator><creator>Ou, Xinrong</creator><creator>Jiang, Haiying</creator><creator>Yao, Zhigang</creator><creator>Xu, Chunjiao</creator><creator>Peng, Jieying</creator><general>S.n.</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200811</creationdate><title>The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis</title><author>Zhou, Shanghui ; Li, Lili ; Jian, Xinchun ; Ou, Xinrong ; Jiang, Haiying ; Yao, Zhigang ; Xu, Chunjiao ; Peng, Jieying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p845-dcb0d31431fd107c79fe6d54c67195173a8a783c0942566939f27ffb030bd06f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>CDC2 Protein Kinase - metabolism</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunoprecipitation</topic><topic>Inhibitor of Apoptosis Proteins</topic><topic>Medical sciences</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Oral Submucous Fibrosis - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Phosphorylation</topic><topic>Precancerous Conditions - metabolism</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Shanghui</creatorcontrib><creatorcontrib>Li, Lili</creatorcontrib><creatorcontrib>Jian, Xinchun</creatorcontrib><creatorcontrib>Ou, Xinrong</creatorcontrib><creatorcontrib>Jiang, Haiying</creatorcontrib><creatorcontrib>Yao, Zhigang</creatorcontrib><creatorcontrib>Xu, Chunjiao</creatorcontrib><creatorcontrib>Peng, Jieying</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Oncology reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Shanghui</au><au>Li, Lili</au><au>Jian, Xinchun</au><au>Ou, Xinrong</au><au>Jiang, Haiying</au><au>Yao, Zhigang</au><au>Xu, Chunjiao</au><au>Peng, Jieying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis</atitle><jtitle>Oncology reports</jtitle><addtitle>Oncol Rep</addtitle><date>2008-11</date><risdate>2008</risdate><volume>20</volume><issue>5</issue><spage>1085</spage><epage>1091</epage><pages>1085-1091</pages><issn>1021-335X</issn><eissn>1791-2431</eissn><abstract>Survivin is a crucial node molecule involved in apoptosis, cell division and drug discovery. Up-regulation of survivin in the tissues of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) originated from OSF has already been demonstrated. Survivin Thr34 phosphorylation is involved in the inhibition of apoptosis and cell division. To determine the potential involvement of survivin Thr34 phosphorylation in carcinogenesis of OSF, 40 OSFs, 42 OSCCs originated from OSF and 10 normal tissues from surgical specimens were studied. Immunohistochemistry showed that the positive staining rate of the survivin phosphorylation on Thr34 in OSCC originated from OSF group was significantly higher than that in OSF group (P<0.01), and none in the normal oral mucosa specimens. Survivin phosphorylation on Thr34 is predominantly located in the nucleus, which account for its function in apoptosis at cell division. Western blotting analysis showed increasing expression of survivin Thr34 phosphorylation, cyclin B1 and p34cdc2 in carcinogenesis of OSF. Furthermore, p34cdc2-cyclin B1 kinase was confirmed to phosphorylate survivin on Thr34 in carcinogenesis of OSF by immunoprecipitation and immunoblot. These results suggest that the phosphorylation of survivin on Thr34 critically regulate survivin and plays an important role during the malignant transformation of OSF, which will provide an indication to early diagnosis and therapy in carcinogenesis of OSF.</abstract><cop>Athens</cop><pub>S.n.</pub><pmid>18949405</pmid><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Blotting, Western Carcinoma, Squamous Cell - metabolism CDC2 Protein Kinase - metabolism Cell Transformation, Neoplastic - metabolism Humans Immunohistochemistry Immunoprecipitation Inhibitor of Apoptosis Proteins Medical sciences Microtubule-Associated Proteins - metabolism Mouth Neoplasms - metabolism Neoplasm Proteins - metabolism Oral Submucous Fibrosis - metabolism Otorhinolaryngology. Stomatology Phosphorylation Precancerous Conditions - metabolism Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis |
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