The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis

Survivin is a crucial node molecule involved in apoptosis, cell division and drug discovery. Up-regulation of survivin in the tissues of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) originated from OSF has already been demonstrated. Survivin Thr34 phosphorylation is involved...

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Veröffentlicht in:	Oncology reports 2008-11, Vol.20 (5), p.1085-1091
Hauptverfasser:	Zhou, Shanghui, Li, Lili, Jian, Xinchun, Ou, Xinrong, Jiang, Haiying, Yao, Zhigang, Xu, Chunjiao, Peng, Jieying
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Carcinoma, Squamous Cell - metabolism CDC2 Protein Kinase - metabolism Cell Transformation, Neoplastic - metabolism Humans Immunohistochemistry Immunoprecipitation Inhibitor of Apoptosis Proteins Medical sciences Microtubule-Associated Proteins - metabolism Mouth Neoplasms - metabolism Neoplasm Proteins - metabolism Oral Submucous Fibrosis - metabolism Otorhinolaryngology. Stomatology Phosphorylation Precancerous Conditions - metabolism Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Zusammenfassung:	Survivin is a crucial node molecule involved in apoptosis, cell division and drug discovery. Up-regulation of survivin in the tissues of oral submucous fibrosis (OSF) and oral squamous cell carcinoma (OSCC) originated from OSF has already been demonstrated. Survivin Thr34 phosphorylation is involved in the inhibition of apoptosis and cell division. To determine the potential involvement of survivin Thr34 phosphorylation in carcinogenesis of OSF, 40 OSFs, 42 OSCCs originated from OSF and 10 normal tissues from surgical specimens were studied. Immunohistochemistry showed that the positive staining rate of the survivin phosphorylation on Thr34 in OSCC originated from OSF group was significantly higher than that in OSF group (P
ISSN:	1021-335X 1791-2431