Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats
Department of Foods and Nutrition, University of Georgia, Athens, Georgia Submitted 17 March 2008 ; accepted in final form 13 October 2008 Rats exposed to 3 h of restraint stress on each of 3 days (RRS) lose weight on the days of RRS and gain weight at the same rate as controls after stress ends, bu...
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container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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creator | Chotiwat, Christina Harris, Ruth B. S |
description | Department of Foods and Nutrition, University of Georgia, Athens, Georgia
Submitted 17 March 2008
; accepted in final form 13 October 2008
Rats exposed to 3 h of restraint stress on each of 3 days (RRS) lose weight on the days of RRS and gain weight at the same rate as controls after stress ends, but do not return to the weight of controls. RRS rats also show an exaggerated endocrine response to subsequent novel stressors. Studies described here tested the effects of corticotropin-releasing factor receptor (CRFR) antagonism on RRS-induced weight loss, hypophagia, and corticosterone release during mild stress in the postrestraint period. Weight loss was not prevented by either peripheral or third-ventricle administration of a CRFR1 antagonist, antalarmin, before each restraint. Antalarmin did, however, allow recovery of body weight in the poststress period. Third-ventricle administration of a CRFR2 antagonist, antisauvagine 30, had no effect in RRS rats but caused sustained weight loss in control animals. Surprisingly, third-ventricle administration of the nonselective CRFR antagonist, astressin, caused hypophagia and reversible weight loss in control rats. It had no effect in RRS rats. None of the antagonists modified the corticosterone response to RRS or to mild stress in the post-RRS period, but antalarmin suppressed corticosterone during the period of restraint in Control rats. These results suggest that CRFR1 activation is required for the initiation of events that lead to a prolonged down-regulation of body weight in RRS rats. The sustained reduction in body weight is independent of the severity of hypophagia on the days of restraint and of RRS-induced corticosterone release.
third ventricle; hypothalamic-pituitary adrenal axis; food intake; body weight
Address for reprint requests and other correspondence: Ruth B. S. Harris, Dept. of Foods and Nutrition, Univ. of Georgia, Dawson Hall, Athens, GA 30605 (e-mail: harrisrb{at}uga.edu ) |
doi_str_mv | 10.1152/ajpregu.00196.2008 |
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Submitted 17 March 2008
; accepted in final form 13 October 2008
Rats exposed to 3 h of restraint stress on each of 3 days (RRS) lose weight on the days of RRS and gain weight at the same rate as controls after stress ends, but do not return to the weight of controls. RRS rats also show an exaggerated endocrine response to subsequent novel stressors. Studies described here tested the effects of corticotropin-releasing factor receptor (CRFR) antagonism on RRS-induced weight loss, hypophagia, and corticosterone release during mild stress in the postrestraint period. Weight loss was not prevented by either peripheral or third-ventricle administration of a CRFR1 antagonist, antalarmin, before each restraint. Antalarmin did, however, allow recovery of body weight in the poststress period. Third-ventricle administration of a CRFR2 antagonist, antisauvagine 30, had no effect in RRS rats but caused sustained weight loss in control animals. Surprisingly, third-ventricle administration of the nonselective CRFR antagonist, astressin, caused hypophagia and reversible weight loss in control rats. It had no effect in RRS rats. None of the antagonists modified the corticosterone response to RRS or to mild stress in the post-RRS period, but antalarmin suppressed corticosterone during the period of restraint in Control rats. These results suggest that CRFR1 activation is required for the initiation of events that lead to a prolonged down-regulation of body weight in RRS rats. The sustained reduction in body weight is independent of the severity of hypophagia on the days of restraint and of RRS-induced corticosterone release.
third ventricle; hypothalamic-pituitary adrenal axis; food intake; body weight
Address for reprint requests and other correspondence: Ruth B. S. Harris, Dept. of Foods and Nutrition, Univ. of Georgia, Dawson Hall, Athens, GA 30605 (e-mail: harrisrb{at}uga.edu )</description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.00196.2008</identifier><identifier>PMID: 18922964</identifier><identifier>CODEN: AJPRDO</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Animals ; Appetite, Obesity, and Digestion ; Brain ; Corticosterone - blood ; Corticotropin-Releasing Hormone - administration & dosage ; Dose-Response Relationship, Drug ; Eating - drug effects ; Feeding Behavior - drug effects ; Hormones ; Infusions, Parenteral ; Injections, Subcutaneous ; Male ; Peptide Fragments - administration & dosage ; Pituitary gland ; Prosencephalon - drug effects ; Prosencephalon - metabolism ; Prosencephalon - physiopathology ; Pyrimidines - administration & dosage ; Pyrroles - administration & dosage ; Rats ; Rats, Sprague-Dawley ; Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors ; Receptors, Corticotropin-Releasing Hormone - metabolism ; Restraint, Physical ; Rodents ; Stress, Psychological - metabolism ; Stress, Psychological - physiopathology ; Time Factors ; Weight ; Weight Loss - drug effects</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2008-12, Vol.295 (6), p.R1762-R1773</ispartof><rights>Copyright American Physiological Society Dec 2008</rights><rights>Copyright © 2008, American Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-f5b7e35a41b73a889352427f3b0782d883796834113f02463bf0a5a69ecc78243</citedby><cites>FETCH-LOGICAL-c583t-f5b7e35a41b73a889352427f3b0782d883796834113f02463bf0a5a69ecc78243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18922964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chotiwat, Christina</creatorcontrib><creatorcontrib>Harris, Ruth B. S</creatorcontrib><title>Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description>Department of Foods and Nutrition, University of Georgia, Athens, Georgia
Submitted 17 March 2008
; accepted in final form 13 October 2008
Rats exposed to 3 h of restraint stress on each of 3 days (RRS) lose weight on the days of RRS and gain weight at the same rate as controls after stress ends, but do not return to the weight of controls. RRS rats also show an exaggerated endocrine response to subsequent novel stressors. Studies described here tested the effects of corticotropin-releasing factor receptor (CRFR) antagonism on RRS-induced weight loss, hypophagia, and corticosterone release during mild stress in the postrestraint period. Weight loss was not prevented by either peripheral or third-ventricle administration of a CRFR1 antagonist, antalarmin, before each restraint. Antalarmin did, however, allow recovery of body weight in the poststress period. Third-ventricle administration of a CRFR2 antagonist, antisauvagine 30, had no effect in RRS rats but caused sustained weight loss in control animals. Surprisingly, third-ventricle administration of the nonselective CRFR antagonist, astressin, caused hypophagia and reversible weight loss in control rats. It had no effect in RRS rats. None of the antagonists modified the corticosterone response to RRS or to mild stress in the post-RRS period, but antalarmin suppressed corticosterone during the period of restraint in Control rats. These results suggest that CRFR1 activation is required for the initiation of events that lead to a prolonged down-regulation of body weight in RRS rats. The sustained reduction in body weight is independent of the severity of hypophagia on the days of restraint and of RRS-induced corticosterone release.
third ventricle; hypothalamic-pituitary adrenal axis; food intake; body weight
Address for reprint requests and other correspondence: Ruth B. S. Harris, Dept. of Foods and Nutrition, Univ. of Georgia, Dawson Hall, Athens, GA 30605 (e-mail: harrisrb{at}uga.edu )</description><subject>Animals</subject><subject>Appetite, Obesity, and Digestion</subject><subject>Brain</subject><subject>Corticosterone - blood</subject><subject>Corticotropin-Releasing Hormone - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eating - drug effects</subject><subject>Feeding Behavior - drug effects</subject><subject>Hormones</subject><subject>Infusions, Parenteral</subject><subject>Injections, Subcutaneous</subject><subject>Male</subject><subject>Peptide Fragments - administration & dosage</subject><subject>Pituitary gland</subject><subject>Prosencephalon - drug effects</subject><subject>Prosencephalon - metabolism</subject><subject>Prosencephalon - physiopathology</subject><subject>Pyrimidines - administration & dosage</subject><subject>Pyrroles - administration & dosage</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Receptors, Corticotropin-Releasing Hormone - metabolism</subject><subject>Restraint, Physical</subject><subject>Rodents</subject><subject>Stress, Psychological - metabolism</subject><subject>Stress, Psychological - physiopathology</subject><subject>Time Factors</subject><subject>Weight</subject><subject>Weight Loss - drug effects</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV9rFDEUxYModq1-AR8k-ODbrPk3mcQHoRRrCwVB6nPIZJLZLLOTMcm0HfzyZt2tVsGnXHJ_53DvPQC8xmiNcU3e6-0UbT-vEcKSrwlC4glYlQapMJPoKVghymnFMZYn4EVKW4QQo4w-BydYSEIkZyvw42zMug-jTzsYHEyTNd55A02I2ZuQY5j8WEU7WJ382EOnTQ4RRmvstC_S3OZlsgmmgpjsb-2wwF3oikn5vLO-32Q4hJSgH4sq5aj9aDsYdU4vwTOnh2RfHd9T8O3i0835ZXX95fPV-dl1ZWpBc-XqtrG01gy3DdVCSFoTRhpHW9QI0glBG8kFZRhThwjjtHVI15pLa0wBGD0FHw--09zubGfsWKYY1BT9TsdFBe3V353Rb1QfbhXhoiZyb_DuaBDD97ksoXY-GTsMerRhTopLITDmTQHf_gNuwxzHspwq924YIogWiBwgE8tdonW_J8FI7YNVx2DVr2DVPtgievN4hz-SY5IF-HAANuXkdz5aNW2W5MMQ-kVdzMNwY-_zgzORteLqK244UVPninj9f_HDNI9E9Cf1msnE</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Chotiwat, Christina</creator><creator>Harris, Ruth B. S</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081201</creationdate><title>Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats</title><author>Chotiwat, Christina ; Harris, Ruth B. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-f5b7e35a41b73a889352427f3b0782d883796834113f02463bf0a5a69ecc78243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Appetite, Obesity, and Digestion</topic><topic>Brain</topic><topic>Corticosterone - blood</topic><topic>Corticotropin-Releasing Hormone - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eating - drug effects</topic><topic>Feeding Behavior - drug effects</topic><topic>Hormones</topic><topic>Infusions, Parenteral</topic><topic>Injections, Subcutaneous</topic><topic>Male</topic><topic>Peptide Fragments - administration & dosage</topic><topic>Pituitary gland</topic><topic>Prosencephalon - drug effects</topic><topic>Prosencephalon - metabolism</topic><topic>Prosencephalon - physiopathology</topic><topic>Pyrimidines - administration & dosage</topic><topic>Pyrroles - administration & dosage</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Receptors, Corticotropin-Releasing Hormone - metabolism</topic><topic>Restraint, Physical</topic><topic>Rodents</topic><topic>Stress, Psychological - metabolism</topic><topic>Stress, Psychological - physiopathology</topic><topic>Time Factors</topic><topic>Weight</topic><topic>Weight Loss - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chotiwat, Christina</creatorcontrib><creatorcontrib>Harris, Ruth B. S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chotiwat, Christina</au><au>Harris, Ruth B. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>295</volume><issue>6</issue><spage>R1762</spage><epage>R1773</epage><pages>R1762-R1773</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><coden>AJPRDO</coden><abstract>Department of Foods and Nutrition, University of Georgia, Athens, Georgia
Submitted 17 March 2008
; accepted in final form 13 October 2008
Rats exposed to 3 h of restraint stress on each of 3 days (RRS) lose weight on the days of RRS and gain weight at the same rate as controls after stress ends, but do not return to the weight of controls. RRS rats also show an exaggerated endocrine response to subsequent novel stressors. Studies described here tested the effects of corticotropin-releasing factor receptor (CRFR) antagonism on RRS-induced weight loss, hypophagia, and corticosterone release during mild stress in the postrestraint period. Weight loss was not prevented by either peripheral or third-ventricle administration of a CRFR1 antagonist, antalarmin, before each restraint. Antalarmin did, however, allow recovery of body weight in the poststress period. Third-ventricle administration of a CRFR2 antagonist, antisauvagine 30, had no effect in RRS rats but caused sustained weight loss in control animals. Surprisingly, third-ventricle administration of the nonselective CRFR antagonist, astressin, caused hypophagia and reversible weight loss in control rats. It had no effect in RRS rats. None of the antagonists modified the corticosterone response to RRS or to mild stress in the post-RRS period, but antalarmin suppressed corticosterone during the period of restraint in Control rats. These results suggest that CRFR1 activation is required for the initiation of events that lead to a prolonged down-regulation of body weight in RRS rats. The sustained reduction in body weight is independent of the severity of hypophagia on the days of restraint and of RRS-induced corticosterone release.
third ventricle; hypothalamic-pituitary adrenal axis; food intake; body weight
Address for reprint requests and other correspondence: Ruth B. S. Harris, Dept. of Foods and Nutrition, Univ. of Georgia, Dawson Hall, Athens, GA 30605 (e-mail: harrisrb{at}uga.edu )</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>18922964</pmid><doi>10.1152/ajpregu.00196.2008</doi><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Animals Appetite, Obesity, and Digestion Brain Corticosterone - blood Corticotropin-Releasing Hormone - administration & dosage Dose-Response Relationship, Drug Eating - drug effects Feeding Behavior - drug effects Hormones Infusions, Parenteral Injections, Subcutaneous Male Peptide Fragments - administration & dosage Pituitary gland Prosencephalon - drug effects Prosencephalon - metabolism Prosencephalon - physiopathology Pyrimidines - administration & dosage Pyrroles - administration & dosage Rats Rats, Sprague-Dawley Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors Receptors, Corticotropin-Releasing Hormone - metabolism Restraint, Physical Rodents Stress, Psychological - metabolism Stress, Psychological - physiopathology Time Factors Weight Weight Loss - drug effects |
title | Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats |
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