Effects of orally administered bovine lactoperoxidase on dextran sulfate sodium-induced colitis in mice

The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administe...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2008-07, Vol.72 (7), p.1932-1935
Hauptverfasser:	Shin, K.(Morinaga Milk Industry Co. Ltd., Zama, Kanagawa (Japan)), Horigome, A, Yamauchi, K, Takase, M, Yaeshima, T, Iwatsuki, K
Format:	Artikel
Sprache:	eng
Schlagworte:	ADMINISTRACION ORAL ADMINISTRATION ORALE Administration, Oral ALBUMINAS ALBUMINE ALBUMINS Animals Anti-Inflammatory Agents Biological and medical sciences Cattle COLITE COLITIS Colitis - chemically induced Colitis - drug therapy Colitis - pathology Dextran Sulfate dextran sulphate sodium Fundamental and applied biological sciences. Psychology interleukin-6 INTERLEUKINE INTERLEUKINS INTERLEUQUINAS INTESTIN INTESTINES INTESTINOS LACTOPEROXIDASA LACTOPEROXIDASE Lactoperoxidase - administration & dosage Lactoperoxidase - pharmacology Lactoperoxidase - therapeutic use LACTOPEROXYDASE MICE ORAL ADMINISTRATION RATON SOURIS Treatment Outcome
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Zusammenfassung:	The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.70636