Risk of thrombogenicity among nonionic radiocontrast agents
Several contrast agents have been approved in the United States for radiographic imaging purposes. Most of the older ionic, high-osmolar contrast agents are no longer used because of their side effect profile. Therefore, newer nonionic, low or iso-osmolar contrast agents have been widely accepted as...
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| Veröffentlicht in: | The Journal of invasive cardiology 2008-07, Vol.20 (7), p.349 |
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| creator | Georgakis, Alexander Ener, Rasih Atilla Jin, Jianguo Kunapuli, Satya Fiss, David Leech, Stephen H Wolf, Nelson M Van Decker, William A |
| description | Several contrast agents have been approved in the United States for radiographic imaging purposes. Most of the older ionic, high-osmolar contrast agents are no longer used because of their side effect profile. Therefore, newer nonionic, low or iso-osmolar contrast agents have been widely accepted as an alternative due to their improved tolerability and safety. We investigated the thrombogenicity of the 6 different nonionic radiocontrast media in terms of their platelet reactivity and noted some minor differences among them. In the 50% contrast concentration group, all of the nonionic contrast agents inhibited aggregation, whereas in the 10% contrast concentration group, all agents showed similar aggregation curves in comparison to the normal control. At 50% contrast concentration, the inhibitory effect of aggregation appeared to be related to the inhibition of calcium mobilization, which may be one of the mechanistic effects. |
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Most of the older ionic, high-osmolar contrast agents are no longer used because of their side effect profile. Therefore, newer nonionic, low or iso-osmolar contrast agents have been widely accepted as an alternative due to their improved tolerability and safety. We investigated the thrombogenicity of the 6 different nonionic radiocontrast media in terms of their platelet reactivity and noted some minor differences among them. In the 50% contrast concentration group, all of the nonionic contrast agents inhibited aggregation, whereas in the 10% contrast concentration group, all agents showed similar aggregation curves in comparison to the normal control. At 50% contrast concentration, the inhibitory effect of aggregation appeared to be related to the inhibition of calcium mobilization, which may be one of the mechanistic effects.</description><identifier>EISSN: 1557-2501</identifier><identifier>PMID: 18599893</identifier><language>eng</language><publisher>United States</publisher><subject>Blood Platelets - drug effects ; Cardiac Catheterization - methods ; Contrast Media - adverse effects ; Contrast Media - pharmacology ; Coronary Thrombosis - chemically induced ; Coronary Thrombosis - epidemiology ; Coronary Thrombosis - physiopathology ; Dose-Response Relationship, Drug ; Humans ; Iohexol - adverse effects ; Iohexol - analogs & derivatives ; Iohexol - pharmacology ; Iopamidol - adverse effects ; Iopamidol - pharmacology ; Platelet Aggregation - drug effects ; Risk Factors ; Triiodobenzoic Acids - adverse effects ; Triiodobenzoic Acids - pharmacology</subject><ispartof>The Journal of invasive cardiology, 2008-07, Vol.20 (7), p.349</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18599893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Georgakis, Alexander</creatorcontrib><creatorcontrib>Ener, Rasih Atilla</creatorcontrib><creatorcontrib>Jin, Jianguo</creatorcontrib><creatorcontrib>Kunapuli, Satya</creatorcontrib><creatorcontrib>Fiss, David</creatorcontrib><creatorcontrib>Leech, Stephen H</creatorcontrib><creatorcontrib>Wolf, Nelson M</creatorcontrib><creatorcontrib>Van Decker, William A</creatorcontrib><title>Risk of thrombogenicity among nonionic radiocontrast agents</title><title>The Journal of invasive cardiology</title><addtitle>J Invasive Cardiol</addtitle><description>Several contrast agents have been approved in the United States for radiographic imaging purposes. Most of the older ionic, high-osmolar contrast agents are no longer used because of their side effect profile. Therefore, newer nonionic, low or iso-osmolar contrast agents have been widely accepted as an alternative due to their improved tolerability and safety. We investigated the thrombogenicity of the 6 different nonionic radiocontrast media in terms of their platelet reactivity and noted some minor differences among them. In the 50% contrast concentration group, all of the nonionic contrast agents inhibited aggregation, whereas in the 10% contrast concentration group, all agents showed similar aggregation curves in comparison to the normal control. 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| ispartof | The Journal of invasive cardiology, 2008-07, Vol.20 (7), p.349 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Blood Platelets - drug effects Cardiac Catheterization - methods Contrast Media - adverse effects Contrast Media - pharmacology Coronary Thrombosis - chemically induced Coronary Thrombosis - epidemiology Coronary Thrombosis - physiopathology Dose-Response Relationship, Drug Humans Iohexol - adverse effects Iohexol - analogs & derivatives Iohexol - pharmacology Iopamidol - adverse effects Iopamidol - pharmacology Platelet Aggregation - drug effects Risk Factors Triiodobenzoic Acids - adverse effects Triiodobenzoic Acids - pharmacology |
| title | Risk of thrombogenicity among nonionic radiocontrast agents |
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