Calciphylaxis treated by cinacalcet: a medical alternative to parathyroidectomy

Calciphylaxis is a rare necrotizing calcifying arteriolopathy, with a poor prognosis, for which there is currently no effective treatment. One of the major challenges of the therapy is normalizing the calcium-phosphate balance. Therefore, cinacalcet, which inhibit the production of parathormone by n...

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Veröffentlicht in:	La revue de medecine interne 2009-02, Vol.30 (2), p.186
Hauptverfasser:	Prey, S, Sparsa, A, Durox, H, Allot, V, Pommepuy, I, Salem, A, Roux, C, Labrousse, F, Bonnetblanc, J-M
Format:	Artikel
Sprache:	fre
Schlagworte:	Anticoagulants - adverse effects Calciphylaxis - chemically induced Calciphylaxis - drug therapy Cinacalcet Hydrochloride Female Heparin - adverse effects Humans Middle Aged Naphthalenes - therapeutic use Necrosis Skin - pathology
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Beschreibung
Zusammenfassung:	Calciphylaxis is a rare necrotizing calcifying arteriolopathy, with a poor prognosis, for which there is currently no effective treatment. One of the major challenges of the therapy is normalizing the calcium-phosphate balance. Therefore, cinacalcet, which inhibit the production of parathormone by negative feedback, was considered a treatment option to control the evolution of calciphylaxis in a dialysed patient suffering from cholangiocarcinoma.
ISSN:	0248-8663
DOI:	10.1016/j.revmed.2008.04.017