Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine

Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies. Our patient, a 28-year-old Chinese woman, represents the first known reported case of clinicall...

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Veröffentlicht in:	Singapore medical journal 2008-06, Vol.49 (6), p.507-510
Hauptverfasser:	GOH, T. K, PANG, S. M, THIRUMOORTHY, T, GOH, S. G. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anticonvulsants - adverse effects Biological and medical sciences Bullous diseases of the skin Carbamazepine - adverse effects Dermatology Drug Eruptions - etiology Drug Eruptions - pathology Exanthema - chemically induced Exanthema - pathology Female General aspects Humans Medical sciences Skin Diseases, Vesiculobullous - chemically induced Skin Diseases, Vesiculobullous - pathology Stevens-Johnson Syndrome - etiology Stevens-Johnson Syndrome - pathology
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Zusammenfassung:	Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies. Our patient, a 28-year-old Chinese woman, represents the first known reported case of clinically-consistent and histologically-proven acute generalised exanthematous pustulosis and toxic epidermal necrolysis overlap induced by carbamazepine in the English literature.
ISSN:	0037-5675