Inhibition of Restenosis Formation Without Compromising Reendothelialization as a Potential Solution to Thrombosis Following Angioplasty?

Stent thrombosis remains an important problem after the implantation of different stent types. A potential solution to this problem may be vasoactive agents with dual effects on different cell types like C-type natriuretic peptide (CNP). Therefore, in vitro and in vivo effects of CNP were investigat...

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Veröffentlicht in:	Endothelium (New York, N.Y.) N.Y.), 2008, Vol.15 (1-2), p.85-92
Hauptverfasser:	Fuchs, Alexandra Theresia, Kuehnl, Andreas, Pelisek, Jaroslav, Rolland, Pierre Henri, Mekkaoui, Choukri, Netz, Heinrich, Nikol, Sigrid
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiography Angioplasty, Balloon - adverse effects Animals Arteries - cytology C-Type Natriuretic Peptide Cell Proliferation - drug effects Cell Survival - drug effects Cells, Cultured Coloring Agents - metabolism Constriction, Pathologic Disease Models, Animal DNA - genetics Endothelial Cells - cytology Endothelial Cells - drug effects Endothelium, Vascular - physiopathology Evans Blue - metabolism Gene Expression Gene Transfer Techniques Immunohistochemistry Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Natriuretic Peptide, C-Type - administration & dosage Natriuretic Peptide, C-Type - genetics Neointima Formation Nonviral Gene Transfer Reendothelialization Subacute Thrombosis Swine Thrombosis - prevention & control Time Factors Transfection Tunica Intima - drug effects
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Zusammenfassung:	Stent thrombosis remains an important problem after the implantation of different stent types. A potential solution to this problem may be vasoactive agents with dual effects on different cell types like C-type natriuretic peptide (CNP). Therefore, in vitro and in vivo effects of CNP were investigated in a porcine restenotic model. Gene transfer of CNP in cultures of porcine vascular cells revealed up to 30% reduction of growth of smooth muscle cells (p
ISSN:	1062-3329 1029-2373
DOI:	10.1080/10623320802092484