Effect of electroacupuncture on drug-seeking behaviors induced by heroin priming and FosB expression in relevant brain regions
To explore the effect of electroacupuncture on heroin seeking behavior and FosB expression in relevant brain regions. Rat model of heroin relapse behaviors was developed with progressive fixed ratio program,and model rats were randomly divided into 3 groups: a restraint group, a needle retention gro...
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| Veröffentlicht in: | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2008-04, Vol.33 (4), p.299 |
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| container_title | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban |
| container_volume | 33 |
| creator | Wang, Yu-hong Zeng, Li-bo Liu, Yi-jun Hao, Wei Zhang, Fu-qiang Zhou, Wen-hua Liu, Hui-fen Tang, Shuai-en Yang, Guo-dong Chen, Hong-xian |
| description | To explore the effect of electroacupuncture on heroin seeking behavior and FosB expression in relevant brain regions.
Rat model of heroin relapse behaviors was developed with progressive fixed ratio program,and model rats were randomly divided into 3 groups: a restraint group, a needle retention group, and a electroacupuncture group. The heroin seeking behavior was elicited by a small dose of heroin. FosB expression in relevnt brain region was assessed with immunohistochemical technique.
Tests on reinstatement of drug seeking behavior induced by heroin priming showed that compared with the restraint group, active pokes in the electroacupuncture group decreased significantly(P |
| format | Article |
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Rat model of heroin relapse behaviors was developed with progressive fixed ratio program,and model rats were randomly divided into 3 groups: a restraint group, a needle retention group, and a electroacupuncture group. The heroin seeking behavior was elicited by a small dose of heroin. FosB expression in relevnt brain region was assessed with immunohistochemical technique.
Tests on reinstatement of drug seeking behavior induced by heroin priming showed that compared with the restraint group, active pokes in the electroacupuncture group decreased significantly(P<0.05). Compared with the restraint group, the expression of FosB positive nuclei in Acd, Pcg and CeA of rats brain both in the electroacupuncture group and the needle retention group (P<0.05) decreased significantly. In LC, the expression of FosB positive nuclei in the needle retention group decreased significantly compared with the rest</description><identifier>ISSN: 1672-7347</identifier><identifier>PMID: 18460772</identifier><language>chi</language><publisher>China</publisher><subject>Amygdala - metabolism ; Animals ; Behavior, Animal ; Brain - metabolism ; Electroacupuncture - methods ; Heroin Dependence - metabolism ; Heroin Dependence - psychology ; Heroin Dependence - therapy ; Male ; Nucleus Accumbens - metabolism ; Proto-Oncogene Proteins c-fos - biosynthesis ; Random Allocation ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2008-04, Vol.33 (4), p.299</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18460772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yu-hong</creatorcontrib><creatorcontrib>Zeng, Li-bo</creatorcontrib><creatorcontrib>Liu, Yi-jun</creatorcontrib><creatorcontrib>Hao, Wei</creatorcontrib><creatorcontrib>Zhang, Fu-qiang</creatorcontrib><creatorcontrib>Zhou, Wen-hua</creatorcontrib><creatorcontrib>Liu, Hui-fen</creatorcontrib><creatorcontrib>Tang, Shuai-en</creatorcontrib><creatorcontrib>Yang, Guo-dong</creatorcontrib><creatorcontrib>Chen, Hong-xian</creatorcontrib><title>Effect of electroacupuncture on drug-seeking behaviors induced by heroin priming and FosB expression in relevant brain regions</title><title>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</title><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><description>To explore the effect of electroacupuncture on heroin seeking behavior and FosB expression in relevant brain regions.
Rat model of heroin relapse behaviors was developed with progressive fixed ratio program,and model rats were randomly divided into 3 groups: a restraint group, a needle retention group, and a electroacupuncture group. The heroin seeking behavior was elicited by a small dose of heroin. FosB expression in relevnt brain region was assessed with immunohistochemical technique.
Tests on reinstatement of drug seeking behavior induced by heroin priming showed that compared with the restraint group, active pokes in the electroacupuncture group decreased significantly(P<0.05). Compared with the restraint group, the expression of FosB positive nuclei in Acd, Pcg and CeA of rats brain both in the electroacupuncture group and the needle retention group (P<0.05) decreased significantly. In LC, the expression of FosB positive nuclei in the needle retention group decreased significantly compared with the rest</description><subject>Amygdala - metabolism</subject><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Brain - metabolism</subject><subject>Electroacupuncture - methods</subject><subject>Heroin Dependence - metabolism</subject><subject>Heroin Dependence - psychology</subject><subject>Heroin Dependence - therapy</subject><subject>Male</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Proto-Oncogene Proteins c-fos - biosynthesis</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>1672-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRb0A0ar0F5B_IFJiO55kCVULSJW6gXXlxyS1aO3ITiq64dtxeazmju7ozJ25IfNKAiuAC5iRZUpOl2Xbtlw2cEdmVSNkCcDm5GvddWhGGjqKxyxiUGYaJm_GKSINnto49UVC_HC-pxoP6uxCTNR5Oxm0VF_oAWNwng7Rna4zylu6CemJ4ucQMW_OkGzHjD8rP1Id1U_bZyPdk9tOHRMu_-qCvG_Wb6uXYrt7fl09bouhYmIsmEQwpbCNsLUR0Ki6lDWTpmGMV7wBKbEudT4YWCs7A8C17ixWQqGVrWz5gjz8codJn9Dur2FVvOz_H8G_AVZ5W_k</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Wang, Yu-hong</creator><creator>Zeng, Li-bo</creator><creator>Liu, Yi-jun</creator><creator>Hao, Wei</creator><creator>Zhang, Fu-qiang</creator><creator>Zhou, Wen-hua</creator><creator>Liu, Hui-fen</creator><creator>Tang, Shuai-en</creator><creator>Yang, Guo-dong</creator><creator>Chen, Hong-xian</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200804</creationdate><title>Effect of electroacupuncture on drug-seeking behaviors induced by heroin priming and FosB expression in relevant brain regions</title><author>Wang, Yu-hong ; Zeng, Li-bo ; Liu, Yi-jun ; Hao, Wei ; Zhang, Fu-qiang ; Zhou, Wen-hua ; Liu, Hui-fen ; Tang, Shuai-en ; Yang, Guo-dong ; Chen, Hong-xian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-26e7c04d84d5c478a506526c8223138766e50b6727296fc773bbfde14aed69693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2008</creationdate><topic>Amygdala - metabolism</topic><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Brain - metabolism</topic><topic>Electroacupuncture - methods</topic><topic>Heroin Dependence - metabolism</topic><topic>Heroin Dependence - psychology</topic><topic>Heroin Dependence - therapy</topic><topic>Male</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Proto-Oncogene Proteins c-fos - biosynthesis</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yu-hong</creatorcontrib><creatorcontrib>Zeng, Li-bo</creatorcontrib><creatorcontrib>Liu, Yi-jun</creatorcontrib><creatorcontrib>Hao, Wei</creatorcontrib><creatorcontrib>Zhang, Fu-qiang</creatorcontrib><creatorcontrib>Zhou, Wen-hua</creatorcontrib><creatorcontrib>Liu, Hui-fen</creatorcontrib><creatorcontrib>Tang, Shuai-en</creatorcontrib><creatorcontrib>Yang, Guo-dong</creatorcontrib><creatorcontrib>Chen, Hong-xian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yu-hong</au><au>Zeng, Li-bo</au><au>Liu, Yi-jun</au><au>Hao, Wei</au><au>Zhang, Fu-qiang</au><au>Zhou, Wen-hua</au><au>Liu, Hui-fen</au><au>Tang, Shuai-en</au><au>Yang, Guo-dong</au><au>Chen, Hong-xian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of electroacupuncture on drug-seeking behaviors induced by heroin priming and FosB expression in relevant brain regions</atitle><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><date>2008-04</date><risdate>2008</risdate><volume>33</volume><issue>4</issue><spage>299</spage><pages>299-</pages><issn>1672-7347</issn><abstract>To explore the effect of electroacupuncture on heroin seeking behavior and FosB expression in relevant brain regions.
Rat model of heroin relapse behaviors was developed with progressive fixed ratio program,and model rats were randomly divided into 3 groups: a restraint group, a needle retention group, and a electroacupuncture group. The heroin seeking behavior was elicited by a small dose of heroin. FosB expression in relevnt brain region was assessed with immunohistochemical technique.
Tests on reinstatement of drug seeking behavior induced by heroin priming showed that compared with the restraint group, active pokes in the electroacupuncture group decreased significantly(P<0.05). Compared with the restraint group, the expression of FosB positive nuclei in Acd, Pcg and CeA of rats brain both in the electroacupuncture group and the needle retention group (P<0.05) decreased significantly. In LC, the expression of FosB positive nuclei in the needle retention group decreased significantly compared with the rest</abstract><cop>China</cop><pmid>18460772</pmid></addata></record> |
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| ispartof | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2008-04, Vol.33 (4), p.299 |
| issn | 1672-7347 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Amygdala - metabolism Animals Behavior, Animal Brain - metabolism Electroacupuncture - methods Heroin Dependence - metabolism Heroin Dependence - psychology Heroin Dependence - therapy Male Nucleus Accumbens - metabolism Proto-Oncogene Proteins c-fos - biosynthesis Random Allocation Rats Rats, Sprague-Dawley |
| title | Effect of electroacupuncture on drug-seeking behaviors induced by heroin priming and FosB expression in relevant brain regions |
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