Effect of electroacupuncture on drug-seeking behaviors induced by heroin priming and FosB expression in relevant brain regions

To explore the effect of electroacupuncture on heroin seeking behavior and FosB expression in relevant brain regions. Rat model of heroin relapse behaviors was developed with progressive fixed ratio program,and model rats were randomly divided into 3 groups: a restraint group, a needle retention group, and a electroacupuncture group. The heroin seeking behavior was elicited by a small dose of heroin. FosB expression in relevnt brain region was assessed with immunohistochemical technique. Tests on reinstatement of drug seeking behavior induced by heroin priming showed that compared with the restraint group, active pokes in the electroacupuncture group decreased significantly(P