Trans-muconic (t,t-MA) and S-phenilmercapturic acid: two biologic markers of benzene low dose exposure

The aim of our study is the comparison between two different biological exposure index, trans-trans-muconic acid (t,t-MA) and S-phenylmercapturic acid (S-PMA), that are minor metabolites of benzene, in the exposure to low concentrations of benzene, to estimate which shows better correlation with the environmental exposure. The study has been conducted upon a sample of 105 male workers in a petrolchemical plant in Sicily. The environmental monitoring data has shown exposure levels within acceptable limits compared with TLV, and these levels have been confirmed by biological monitoring data. The comparison between biomarkers didn't point out particular differences and this data is probably connected to low found levels of exposure.