In vitro antiviral activity of plant extracts on goatpox virus replication

Four plants having known medicinal properties were screened for inhibition of goatpox virus (GTPV) replication in vitro. Of the 4 plants, extract of Acacia arabica (Babul) and Eugenia jambolana (Jamun) leaves had inhibition (%) 99.70 and 99.92 at their maximum non toxic concentrations, 99.93 +/- 0.3...

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Veröffentlicht in:	Indian journal of experimental biology 2008-02, Vol.46 (2), p.120
Hauptverfasser:	Bhanuprakash, V, Hosamani, M, Balamurugan, V, Gandhale, P, Naresh, Ram, Swarup, D, Singh, R K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acacia Animals Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Capripoxvirus - drug effects Cercopithecus aethiops Cytopathogenic Effect, Viral - drug effects In Vitro Techniques Plant Extracts - pharmacology Plant Leaves Poxviridae Infections - drug therapy Syzygium Vero Cells Virus Replication - drug effects
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Zusammenfassung:	Four plants having known medicinal properties were screened for inhibition of goatpox virus (GTPV) replication in vitro. Of the 4 plants, extract of Acacia arabica (Babul) and Eugenia jambolana (Jamun) leaves had inhibition (%) 99.70 and 99.92 at their maximum non toxic concentrations, 99.93 +/- 0.38 and 1999.73 +/- 0.50 microg/ml, respectively in all cytopathic effect (CPE) inhibition assays. Inhibition of GTPV virus replication was further confirmed by PCR and SYBR Green based quantitative real-time QPCR assays specific for GTPV. Results indicated that the extract of Acacia arabica and Eugenia jambolana leaves inhibited GTPV replication in vitro.
ISSN:	0019-5189