Proprioceptive and Cutaneous Representations in the Rat Ventral Posterolateral Thalamus

1 Department of Physiology and Pharmacology, 2 Program in Neural and Behavioral Science, and 3 Program in Biomedical Engineering, State University of New York Downstate Medical Center, Brooklyn, New York Submitted 29 October 2007; accepted in final form 18 February 2008 Determining how and where proprioceptive information is represented in the rat ventral posterolateral (VPL) is important in allowing us to further investigate how this sense is utilized during motor control and learning. Here we demonstrate using electrophysiological techniques that the rostral portion of the rat VPL nucleus (rVPL, –2 to –2.5 mm bregma) carries a large amount of proprioceptive information. Caudal to this region is a zone where the cutaneous receptive fields are focal (mVPL for middle VPL, –2.5 to –3.2 mm bregma) with a fine topographic map of the fore- and hindlimbs. The forepaw is represented with digit 1 medial and each subsequent digit increasingly lateral, all of which are dorsal to the pads. The caudal VPL (cVPL, –3.2 to –4.0 mm bregma) has broad receptive fields and is the target of lamina 1 and lamina 2, as well as the dorsal column nuclei, and may represent the flow of nociceptive information through the VPL. Thus we propose that the VPL may be thought of as three subnuclei—the rostral, middle, and caudal VPL—each carrying preferentially a different modality of information. This pattern of information flow through the rat VPL is similar, although apparently rotated, to that of many primates, indicating that these regions in the rat (rVPL, mVPL, and cVPL) have become further differentiated in primates where they are seen as separate nuclei (VPS, VPL, and VPI/VMpo). Address for reprint requests and other correspondence: J. T. Francis, Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Ave., Box 31, Brooklyn, NY 11203 (E-mail: joe.francis{at}downstate.edu )