Antitumor Effect of Acridine Orange Under Ultrasonic Irradiation In Vitro

Background: Sonodynamic synergistic antitumor therapy is a promising new methodology for cancer treatment. Materials and Methods: To determine the antitumor effects of ultrasound (US) in the presence of acridine orange (AO), 1.0 Î¼g/ml solution of AO was tested as a sonodynamic compound against sarc...

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Veröffentlicht in:	Anticancer research 2007-11, Vol.27 (6B), p.4179-4184
Hauptverfasser:	SUZUKI, Norio, OKADA, Kyoji, CHIDA, Shuichi, KOMORI, Chiyo, SHIMADA, Yoichi, SUZUKI, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridine Orange - pharmacology Animals Apoptosis - drug effects Biological and medical sciences Free Radical Scavengers - pharmacology Male Medical sciences Mice Mice, Inbred ICR Reactive Oxygen Species - metabolism Sarcoma 180 - diagnostic imaging Sarcoma 180 - drug therapy Sarcoma 180 - metabolism Sarcoma 180 - therapy Tumors Ultrasonic Therapy - methods Ultrasonography
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Zusammenfassung:	Background: Sonodynamic synergistic antitumor therapy is a promising new methodology for cancer treatment. Materials and Methods: To determine the antitumor effects of ultrasound (US) in the presence of acridine orange (AO), 1.0 Î¼g/ml solution of AO was tested as a sonodynamic compound against sarcoma 180 cells in vitro. Results: After US irradiation at 2.0 W/cm 2 for 60 sec, the survival rate of tumor cells in the presence of AO was significantly lower than in its absence (p
ISSN:	0250-7005 1791-7530