Tiletamine-zolazepam and xylazine is a potent cardiodepressive combination: a case report

Intramuscular injection of tiletamine-zolazepam and xylazine is commonly used as a preanesthetic for veterinary surgical procedures and for short-term restraint. However, this combination can have marked cardiodepressive and hypothermic effects that persist for hours to days. Here we present a case...

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Veröffentlicht in:	Journal of the American Association for Laboratory Animal Science 2007-11, Vol.46 (6), p.63-64
Hauptverfasser:	Lefkov, S.H, Mussig, D
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects animal disease models Animals Animals, Laboratory Anti-Arrhythmia Agents - adverse effects benzodiazepines Body Temperature - drug effects cardiac output cardiodepression combination drug therapy Disease Models, Animal Drug Combinations Female Heart - drug effects heart diseases Heart Failure - chemically induced Heart Failure - diagnosis Heart Failure - veterinary heart failure model heart rate hypothermia Hypothermia - chemically induced Hypothermia - veterinary miniature swine preanesthetic medication Surgery, Veterinary - methods Sus scrofa Swine Swine Diseases - chemically induced Swine Diseases - diagnosis tiletamine Tiletamine - adverse effects xylazine Xylazine - adverse effects Zolazepam - adverse effects
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Beschreibung
Zusammenfassung:	Intramuscular injection of tiletamine-zolazepam and xylazine is commonly used as a preanesthetic for veterinary surgical procedures and for short-term restraint. However, this combination can have marked cardiodepressive and hypothermic effects that persist for hours to days. Here we present a case report of these effects in a swine heart failure model.
ISSN:	1559-6109 2769-6677