Accelerated chronological aging of a mutant fission yeast deficient in both glutathione and superoxide dismutase having Cu and Zn as cofactors and its enhancement by sir2 deficiency

A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-11, Vol.71 (11), p.2841-2844
Hauptverfasser:	Mutoh, N.(Aichi-ken Human Service Center, Kasugai (Japan). Inst. for Developmental Research), Kitajima, S
Format:	Artikel
Sprache:	eng
Schlagworte:	AGING Biological and medical sciences chronological aging CLOSTRIDIUM THERMOCELLUM Coenzymes - metabolism COFACTEUR COFACTORS Copper - metabolism Drug Resistance, Fungal - genetics ENVEJECIMIENTO ESPECIES DE OXIGENO REACTIVO Fundamental and applied biological sciences. Psychology glutathione Glutathione - deficiency MUTANT MUTANTES MUTANTS Mutation REACTIVE OXYGEN SPECIES Schizosaccharomyces - enzymology Schizosaccharomyces - genetics Schizosaccharomyces - growth & development SCHIZOSACCHAROMYCES POMBE Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism sir2 SUPEROXIDE DISMUTASE Superoxide Dismutase - genetics SUPEROXIDO DISMUTASA SUPEROXYDE DISMUTASE VIEILLISSEMENT Vitamin K 3 - pharmacology Vitamins - pharmacology Zinc - metabolism
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Zusammenfassung:	A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of the sir2 gene in the double mutant enhanced the short chronological lifespan without more enhanced protein oxidation.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.70307