Solubilization of components of outer membrane of Leptospira interrogans serovar mozdok by sodium desoxycholate and triton X-100 and evaluation of their immunogenic capacity and homologous and heterologous protection induced in hamsters

Two detergents (triton X-100 and sodium desoxycholate) were evaluated as solubilizing agents of the components of the outer membrane of Leptospira Pomona serovar mozdok. It was obtained a greater yielding of proteins on applying the treatment with triton X-100. The variants formulated starting from...

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Veröffentlicht in:	Revista cubana de medicina tropical 2005-01, Vol.57 (1), p.53
Hauptverfasser:	Rivera, Yovania Fernández, Navarro, Yadira Pino, Mazorra, Yisabel Aranguren, Rodríguez, Andrés González, Padrón, María de los Angeles, Valdés, Yolanda
Format:	Artikel
Sprache:	spa
Schlagworte:	Animals Antibodies, Bacterial - blood Bacterial Outer Membrane Proteins - immunology Bacterial Vaccines - immunology Cricetinae Deoxycholic Acid - pharmacology Disease Models, Animal Leptospira interrogans - immunology Leptospira interrogans - pathogenicity Leptospira interrogans serovar canicola - immunology Leptospirosis - immunology Leptospirosis - prevention & control Lethal Dose 50 Octoxynol - pharmacology
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Zusammenfassung:	Two detergents (triton X-100 and sodium desoxycholate) were evaluated as solubilizing agents of the components of the outer membrane of Leptospira Pomona serovar mozdok. It was obtained a greater yielding of proteins on applying the treatment with triton X-100. The variants formulated starting from the extracts obtained showed a high immunogenicity and capacity of homologous protection against the challenge in hamster.
ISSN:	0375-0760