K Channel Pharmacogenomics: From Bench to Bedside

Inheritance plays a significant role in defining drug response and toxicity. Advances in molecular pharmacology and modern genomics emphasize genetic variation in dictating inter-individual pharmacokinetics and pharmacodynamics. A case in point is the homeostatic ATP-sensitive potassium (K(ATP)) cha...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2008-02, Vol.83 (2), p.354-357
Hauptverfasser:	Sattiraju, S, Reyes, S, Kane, G C, Terzic, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - pharmacology Anti-Arrhythmia Agents - therapeutic use Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism ATP-Binding Cassette Transporters - drug effects ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Congenital Hyperinsulinism - drug therapy Congenital Hyperinsulinism - genetics Congenital Hyperinsulinism - metabolism Diabetes Mellitus - drug therapy Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Drug Design Humans Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Infant, Newborn Infant, Newborn, Diseases - drug therapy Infant, Newborn, Diseases - genetics Infant, Newborn, Diseases - metabolism Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism KATP Channels - drug effects KATP Channels - genetics KATP Channels - metabolism Patient Selection Pharmacogenetics Polymorphism, Genetic Potassium Channel Blockers - pharmacology Potassium Channel Blockers - therapeutic use Potassium Channels - drug effects Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying - drug effects Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism Receptors, Drug - drug effects Receptors, Drug - genetics Receptors, Drug - metabolism Sulfonylurea Receptors
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Beschreibung
Zusammenfassung:	Inheritance plays a significant role in defining drug response and toxicity. Advances in molecular pharmacology and modern genomics emphasize genetic variation in dictating inter-individual pharmacokinetics and pharmacodynamics. A case in point is the homeostatic ATP-sensitive potassium (K(ATP)) channel, an established drug target that adjusts membrane excitability to match cellular energetic demand. There is an increased recognition that genetic variability of the K(ATP) channel impacts therapeutic decision-making in human disease.
ISSN:	0009-9236 1532-6535
DOI:	10.1038/sj.clpt.6100378