Associations of methylenetetrahydrofolate reductase C677T polymorphism with markers of subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study

Objective. To study whether the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism or serum homocysteine concentration is associated with carotid artery intima media thickness (IMT), carotid artery compliance (CAC) or brachial artery flow mediated dilatation (FMD) in a healthy Finnish ad...

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Veröffentlicht in:	Scandinavian journal of clinical and laboratory investigation 2008-01, Vol.68 (1), p.22-30
Hauptverfasser:	Collings, A., Raitakari, O. T., Juonala, M., Rontu, R., Kähönen, M., Hutri-Kähönen, N., Rönnemaa, T., Marniemi, J., Viikari, J. S. A., Lehtimäki, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Apolipoprotein A-I - blood Atherosclerosis Atherosclerosis - blood Atherosclerosis - genetics Atherosclerosis - pathology Biomarkers - blood Blood Glucose - analysis Blood Pressure Body Mass Index Brachial Artery - pathology Brachial Artery - physiopathology Carotid Arteries - pathology Carotid Arteries - physiopathology Female Finland Gene Frequency homocysteine Homocysteine - blood Humans Lipids - blood Male methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) - genetics Multivariate Analysis Polymorphism, Single Nucleotide Risk Factors Sex Factors SNP Tunica Intima - pathology Tunica Intima - physiopathology Vasodilation
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Zusammenfassung:	Objective. To study whether the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism or serum homocysteine concentration is associated with carotid artery intima media thickness (IMT), carotid artery compliance (CAC) or brachial artery flow mediated dilatation (FMD) in a healthy Finnish adult population. Methods. Cross-sectional data obtained in 2001 for the Cardiovascular Risk in Young Finns Study were used. Carotid artery IMT, CAC and brachial FMD were measured by ultrasound and serum homocysteine concentrations using a commercial immunoassay kit. We studied 1,440 subjects (aged 24-39 years). Genotyping was performed using the 5′ nuclease TaqMan assay. Results. Homocysteine values differed between genotypes in women and men (ANOVA, p
ISSN:	0036-5513 1502-7686
DOI:	10.1080/00365510701487735