Hematopoietic stem cell therapy for malignant diseases

Allogeneic bone marrow or blood stem cell transplantation (SCT) has changed its face in the last two decades. The introduction of nonmyeloablative conditioning regimens has reduced procedure toxicity and allowed the application of SCT in patients and conditions in which SCT was not offered in the pa...

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Veröffentlicht in:	Annals of medicine (Helsinki) 2007, Vol.39 (6), p.465-473
Hauptverfasser:	Shapira, Michael Y., Abdul Hai, Ali, Tsirigotis, Panagiotis, Resnick, Igor B., Or, Reuven, Slavin, Shimon
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Applied cell therapy and gene therapy Biological and medical sciences Donor lymphocyte infusion (DLI) General aspects Graft vs Host Disease - prevention & control graft-versus-host disease (GVHD) graft-versus-leukemia (GVL) graft-versus-tumor (GVT) effects Hematologic Neoplasms - therapy Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - trends Humans Medical sciences nonmyeloablative conditioning nonmyeloablative stem cell transplantation (NST) reduced intensity conditioning (RIC) stem cell transplantation (SCT) Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Conditioning - methods
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Beschreibung
Zusammenfassung:	Allogeneic bone marrow or blood stem cell transplantation (SCT) has changed its face in the last two decades. The introduction of nonmyeloablative conditioning regimens has reduced procedure toxicity and allowed the application of SCT in patients and conditions in which SCT was not offered in the past. In this review we will summarize the changes and accomplishments achieved in the past years in the field of stem cell transplantation for malignant disorders.
ISSN:	0785-3890 1365-2060
DOI:	10.1080/07853890701472323