Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea [Camellia sinensis] catechins and black tea theaflavins
In the course of screening for 17alpha-hydroxylase/Csub(17,20)-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and the...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-09, Vol.71 (9), p.2325 |
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| creator | Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture) Itakura, Y Goto, R Tojima, M Egawa, N Yoshihama, M |
| description | In the course of screening for 17alpha-hydroxylase/Csub(17,20)-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited Csub(17,20)-lyase activity on ICsub(50) values of 24.5 microM and 11.5 microM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (ICsub(50)=28.1 microM and 37.4 microM). |
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Faculty of Agriculture) ; Itakura, Y ; Goto, R ; Tojima, M ; Egawa, N ; Yoshihama, M</creator><creatorcontrib>Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture) ; Itakura, Y ; Goto, R ; Tojima, M ; Egawa, N ; Yoshihama, M</creatorcontrib><description>In the course of screening for 17alpha-hydroxylase/Csub(17,20)-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited Csub(17,20)-lyase activity on ICsub(50) values of 24.5 microM and 11.5 microM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (ICsub(50)=28.1 microM and 37.4 microM).</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>PMID: 17827674</identifier><language>eng</language><publisher>England</publisher><subject>AGENTES ANTINEOPLASTICOS ; Animals ; ANTINEOPLASTIC AGENTS ; Biflavonoids - pharmacology ; CATECHIN ; Catechin - pharmacology ; CATECHINE ; CATEQUINA ; Color ; ENZYME INHIBITORS ; Enzyme Inhibitors - chemistry ; Enzyme Inhibitors - pharmacology ; EXTRACTOS VEGETALES ; EXTRAIT D'ORIGINE VEGETALE ; Gonadal Steroid Hormones - biosynthesis ; Gonadal Steroid Hormones - chemistry ; INHIBIDORES DE ENZIMAS ; INHIBITEUR D'ENZYME ; Inhibitory Concentration 50 ; LIASAS ; LYASE ; LYASES ; Male ; MEDICAMENT CYTOSTATIQUE ; Molecular Structure ; PLANT EXTRACTS ; RAT ; RATA ; RATS ; Steroid 17-alpha-Hydroxylase - metabolism ; Structure-Activity Relationship ; TEA ; Tea - chemistry ; Testis - drug effects ; Testis - enzymology ; THE</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2007-09, Vol.71 (9), p.2325</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17827674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Itakura, Y</creatorcontrib><creatorcontrib>Goto, R</creatorcontrib><creatorcontrib>Tojima, M</creatorcontrib><creatorcontrib>Egawa, N</creatorcontrib><creatorcontrib>Yoshihama, M</creatorcontrib><title>Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea [Camellia sinensis] catechins and black tea theaflavins</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>In the course of screening for 17alpha-hydroxylase/Csub(17,20)-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited Csub(17,20)-lyase activity on ICsub(50) values of 24.5 microM and 11.5 microM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (ICsub(50)=28.1 microM and 37.4 microM).</description><subject>AGENTES ANTINEOPLASTICOS</subject><subject>Animals</subject><subject>ANTINEOPLASTIC AGENTS</subject><subject>Biflavonoids - pharmacology</subject><subject>CATECHIN</subject><subject>Catechin - pharmacology</subject><subject>CATECHINE</subject><subject>CATEQUINA</subject><subject>Color</subject><subject>ENZYME INHIBITORS</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>EXTRACTOS VEGETALES</subject><subject>EXTRAIT D'ORIGINE VEGETALE</subject><subject>Gonadal Steroid Hormones - biosynthesis</subject><subject>Gonadal Steroid Hormones - chemistry</subject><subject>INHIBIDORES DE ENZIMAS</subject><subject>INHIBITEUR D'ENZYME</subject><subject>Inhibitory Concentration 50</subject><subject>LIASAS</subject><subject>LYASE</subject><subject>LYASES</subject><subject>Male</subject><subject>MEDICAMENT CYTOSTATIQUE</subject><subject>Molecular Structure</subject><subject>PLANT EXTRACTS</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Steroid 17-alpha-Hydroxylase - metabolism</subject><subject>Structure-Activity Relationship</subject><subject>TEA</subject><subject>Tea - chemistry</subject><subject>Testis - drug effects</subject><subject>Testis - enzymology</subject><subject>THE</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kM1KxDAcxIMo7rr6CEqOChbz1aQ9SvFjRXAPehCR8k-bbKNpuyRV7DP40hZXT8PM_JjD7KA55UIlMhdqF81JTmWSiZTO0EGMb4RMQUr30YyqjCmpxBx9L7vGaTe4vsO9xVSB3zSQNGMd-q_RQzQXBVXnjCR-nAw-LZ5XVJ1hG_oWBxjwYOLgItYjXgdjuskDfimgNd47wNF1posuvuIKBlM1rosYuhprD9X7Lzs0BqyHz6k5RHsWfDRHf7pAT9dXj8Vtcv9wsywu7xNLGRGJtRSkyLIcpBY1s1yzPLVVBpzktpaKAGec2hyMkobKXJuaUSJ0WmsOVKd8gU62u5sP3Zq63ATXQhjL_1cm4HgLWOhLWAcXy7sVIyQjhPJp_AcrGWgy</recordid><startdate>200709</startdate><enddate>200709</enddate><creator>Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creator><creator>Itakura, Y</creator><creator>Goto, R</creator><creator>Tojima, M</creator><creator>Egawa, N</creator><creator>Yoshihama, M</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>200709</creationdate><title>Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea [Camellia sinensis] catechins and black tea theaflavins</title><author>Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture) ; Itakura, Y ; Goto, R ; Tojima, M ; Egawa, N ; Yoshihama, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f1204-ff1a64889a6b4d2f3b295fc8a309fd670a3231f9ae76e169bed2104b5db3a1b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>AGENTES ANTINEOPLASTICOS</topic><topic>Animals</topic><topic>ANTINEOPLASTIC AGENTS</topic><topic>Biflavonoids - pharmacology</topic><topic>CATECHIN</topic><topic>Catechin - pharmacology</topic><topic>CATECHINE</topic><topic>CATEQUINA</topic><topic>Color</topic><topic>ENZYME INHIBITORS</topic><topic>Enzyme Inhibitors - chemistry</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>EXTRACTOS VEGETALES</topic><topic>EXTRAIT D'ORIGINE VEGETALE</topic><topic>Gonadal Steroid Hormones - biosynthesis</topic><topic>Gonadal Steroid Hormones - chemistry</topic><topic>INHIBIDORES DE ENZIMAS</topic><topic>INHIBITEUR D'ENZYME</topic><topic>Inhibitory Concentration 50</topic><topic>LIASAS</topic><topic>LYASE</topic><topic>LYASES</topic><topic>Male</topic><topic>MEDICAMENT CYTOSTATIQUE</topic><topic>Molecular Structure</topic><topic>PLANT EXTRACTS</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Steroid 17-alpha-Hydroxylase - metabolism</topic><topic>Structure-Activity Relationship</topic><topic>TEA</topic><topic>Tea - chemistry</topic><topic>Testis - drug effects</topic><topic>Testis - enzymology</topic><topic>THE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture)</creatorcontrib><creatorcontrib>Itakura, Y</creatorcontrib><creatorcontrib>Goto, R</creatorcontrib><creatorcontrib>Tojima, M</creatorcontrib><creatorcontrib>Egawa, N</creatorcontrib><creatorcontrib>Yoshihama, M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture)</au><au>Itakura, Y</au><au>Goto, R</au><au>Tojima, M</au><au>Egawa, N</au><au>Yoshihama, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea [Camellia sinensis] catechins and black tea theaflavins</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2007-09</date><risdate>2007</risdate><volume>71</volume><issue>9</issue><spage>2325</spage><pages>2325-</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>In the course of screening for 17alpha-hydroxylase/Csub(17,20)-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited Csub(17,20)-lyase activity on ICsub(50) values of 24.5 microM and 11.5 microM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (ICsub(50)=28.1 microM and 37.4 microM).</abstract><cop>England</cop><pmid>17827674</pmid></addata></record> |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Free Full-Text Journals in Chemistry |
| subjects | AGENTES ANTINEOPLASTICOS Animals ANTINEOPLASTIC AGENTS Biflavonoids - pharmacology CATECHIN Catechin - pharmacology CATECHINE CATEQUINA Color ENZYME INHIBITORS Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE Gonadal Steroid Hormones - biosynthesis Gonadal Steroid Hormones - chemistry INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME Inhibitory Concentration 50 LIASAS LYASE LYASES Male MEDICAMENT CYTOSTATIQUE Molecular Structure PLANT EXTRACTS RAT RATA RATS Steroid 17-alpha-Hydroxylase - metabolism Structure-Activity Relationship TEA Tea - chemistry Testis - drug effects Testis - enzymology THE |
| title | Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea [Camellia sinensis] catechins and black tea theaflavins |
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