Inhibition of 17alpha-hydroxylase/C17,20-lyase (CYP17) from rat testis by green tea [Camellia sinensis] catechins and black tea theaflavins

In the course of screening for 17alpha-hydroxylase/Csub(17,20)-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and the...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2007-09, Vol.71 (9), p.2325
Hauptverfasser:	Kimura, K.(Iwate Univ., Morioka (Japan). Faculty of Agriculture), Itakura, Y, Goto, R, Tojima, M, Egawa, N, Yoshihama, M
Format:	Artikel
Sprache:	eng
Schlagworte:	AGENTES ANTINEOPLASTICOS Animals ANTINEOPLASTIC AGENTS Biflavonoids - pharmacology CATECHIN Catechin - pharmacology CATECHINE CATEQUINA Color ENZYME INHIBITORS Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE Gonadal Steroid Hormones - biosynthesis Gonadal Steroid Hormones - chemistry INHIBIDORES DE ENZIMAS INHIBITEUR D'ENZYME Inhibitory Concentration 50 LIASAS LYASE LYASES Male MEDICAMENT CYTOSTATIQUE Molecular Structure PLANT EXTRACTS RAT RATA RATS Steroid 17-alpha-Hydroxylase - metabolism Structure-Activity Relationship TEA Tea - chemistry Testis - drug effects Testis - enzymology THE
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Zusammenfassung:	In the course of screening for 17alpha-hydroxylase/Csub(17,20)-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited Csub(17,20)-lyase activity on ICsub(50) values of 24.5 microM and 11.5 microM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (ICsub(50)=28.1 microM and 37.4 microM).
ISSN:	0916-8451 1347-6947