Effects of paraquat on anti-oxidant system in rats

The toxic effects of paraquat on the anti-oxidant defense system of male albino rats were evaluated, after administering either a single dose (1.5 and 7.5 mg/kg of body weight) or continuous daily doses (same as above, i.e., 1.5 mg/kg and 7.5 mg/kg of body weight) for 3 and 7 days. Glutathione level...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Indian journal of experimental biology 2007-05, Vol.45 (5), p.432
Hauptverfasser:	Ray, Sanhita, Sengupta, Arnab, Ray, Amitabha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - analysis Antioxidants - metabolism Catalase - analysis Catalase - metabolism Dose-Response Relationship, Drug Erythrocytes - chemistry Erythrocytes - enzymology Glucosephosphate Dehydrogenase - analysis Glucosephosphate Dehydrogenase - metabolism Glutathione - analysis Glutathione Peroxidase - analysis Glutathione Peroxidase - metabolism Glutathione Reductase - analysis Glutathione Reductase - metabolism Glutathione Transferase - analysis Glutathione Transferase - metabolism Kidney - chemistry Kidney - enzymology Lipid Peroxidation - drug effects Liver - chemistry Liver - enzymology Lung - chemistry Lung - enzymology Male Oxidative Stress - drug effects Paraquat - toxicity Rats Rats, Wistar Superoxide Dismutase - analysis Superoxide Dismutase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The toxic effects of paraquat on the anti-oxidant defense system of male albino rats were evaluated, after administering either a single dose (1.5 and 7.5 mg/kg of body weight) or continuous daily doses (same as above, i.e., 1.5 mg/kg and 7.5 mg/kg of body weight) for 3 and 7 days. Glutathione levels in blood cells, liver, lung and kidney tissues decreased in a dose and time dependent manner. Glutathione reductase and glucose-6-phosphate dehydrogenase activity decreased, whereas the activity of glutathione-S-transferase, glutathione peroxidase, catalase and superoxide dismutase increased in paraquat exposure. Malondialdehyde formation also increased in a dose and time dependent manner. The alterations of anti-oxidant system particularly glutathione can be utilized as biomarkers during management of paraquat poisoning.
ISSN:	0019-5189